AP3D_DICDI
ID AP3D_DICDI Reviewed; 1143 AA.
AC Q54WN0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=AP-3 complex subunit delta;
DE AltName: Full=Adaptor-related protein complex 3 subunit delta;
DE AltName: Full=Delta-adaptin;
GN Name=ap3d1; ORFNames=DDB_G0279537;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC essential for the compartmentalization of the endocytic pathway.
CC -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC of two large adaptins (delta-type subunit and beta-type subunit), a
CC medium adaptin (mu-type subunit) and a small adaptin (sigma-type
CC subunit). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000031; EAL67707.1; -; Genomic_DNA.
DR RefSeq; XP_641687.1; XM_636595.1.
DR AlphaFoldDB; Q54WN0; -.
DR SMR; Q54WN0; -.
DR STRING; 44689.DDB0234240; -.
DR PaxDb; Q54WN0; -.
DR PRIDE; Q54WN0; -.
DR EnsemblProtists; EAL67707; EAL67707; DDB_G0279537.
DR GeneID; 8622095; -.
DR KEGG; ddi:DDB_G0279537; -.
DR dictyBase; DDB_G0279537; ap3d1.
DR eggNOG; KOG1059; Eukaryota.
DR HOGENOM; CLU_001908_0_0_1; -.
DR InParanoid; Q54WN0; -.
DR OMA; ECIQTCI; -.
DR PhylomeDB; Q54WN0; -.
DR PRO; PR:Q54WN0; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0030123; C:AP-3 adaptor complex; IDA:dictyBase.
DR GO; GO:0010008; C:endosome membrane; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR InterPro; IPR017105; AP3_complex_dsu.
DR InterPro; IPR010474; AP3D_dom_metazoa.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR PANTHER; PTHR22781; PTHR22781; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SMART; SM01354; BLVR; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Coiled coil; Endosome; Membrane; Protein transport; Reference proteome;
KW Repeat; Transport.
FT CHAIN 1..1143
FT /note="AP-3 complex subunit delta"
FT /id="PRO_0000328025"
FT REPEAT 129..166
FT /note="HEAT 1"
FT REPEAT 167..203
FT /note="HEAT 2"
FT REPEAT 205..242
FT /note="HEAT 3"
FT REPEAT 245..279
FT /note="HEAT 4"
FT REPEAT 280..317
FT /note="HEAT 5"
FT REPEAT 318..354
FT /note="HEAT 6"
FT REPEAT 356..389
FT /note="HEAT 7"
FT REPEAT 416..455
FT /note="HEAT 8"
FT DOMAIN 914..1016
FT /note="GAE"
FT REGION 520..541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 634..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..728
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 829..899
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 526..550
FT /evidence="ECO:0000255"
FT COILED 814..835
FT /evidence="ECO:0000255"
FT COMPBIAS 523..539
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 835..849
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1143 AA; 127858 MW; 3673B1DB3BC7C348 CRC64;
MFERTLVDLI RGIRNHKKNE TKFINQCINE IKEELKGDMQ KKTVAVQKLT YIQMLGFDIS
WASFKIVEVM SCNKFSSKRI GYLAASQSFN EGTDVIVLAT HQIRKDFLSS NQSEAYLALN
CLSNICTTDL ARELANDILT LLSTQKTHIL KRAITVLYKI FLRYPESLRP AFPKLREKLD
DPEPSVVSCS VNVICELARR NPKNYLPLAP VLFRILTNTT NNYWMLIKIV KLFAALTPHE
PRLGKKLIDP LTNIINSSPS VSLLYECIQT CITGMSDHIP LMKLCISKLR TLIEHNDQNL
KYLGLLALNN IMKIHPKAVS EHRDLVLNCL EDDDISIRLR ALDLLPGMTS KKNIGDIVFK
LLDHLDNAEG QYKEQIIEKI IELCSMGTYQ FITDFEWYIN ILVKLSQIQD SIHGKLIASQ
LLDVVIRVKI VRAYSTRQMI ELLKNPKLMS NPTEGGMCEV LYAAAWIVGE FSGYVNRPID
ALEAFLQPRV CVLPSHIQSV YMLNSLKVFS HACAKANGDK IPSLDDDDEE EEAQEEEDQN
EITHEIVQEC LEIIKSRLTI FTHSIYLNVQ ERACLINELL SFYTVTKEQG NNISKELISL
FTEQLNPVGP KAQKKVPIPE GLDLDEWIND PKHQEPIEED EDDDIFNTST SSHQKKHHKH
HRGGYDGDDD EDDETNSSHS GHSSSNFNRH PIDIQRQKEE RLRKQANNPY MLGGKVSKKL
STNDPENIPV VQLTGDLGHL HVGASSNRPM PSKGSKKTKK HYTIDTTTEM PEGAKESDDE
DEKDNKYKND ALSNINLSEP LTASDVLHTS RHRTDIIKEK EREMAMLAKK NAKLSPKSPP
STANYSEVTS PEIAPAKKAT KKAAAGSNPP PPPTAKKSSK KPAATSSTTT TTKSTQAAAA
VVAPPPVIVK KVLKTILDDD NFKITCEILK VSPSNETDNN QIKLTMKVQN KTDEDMSDVS
ISLKNPAEQC VSIKNSGEIG VLEADASTTH TELLNVVNVL NSQELQFTLL ASPSSSPSIT
NQLSIDLPFS FFIVATKLPK DKFAEILQKS GQVSAMDSTK ITGQSLTMPL VIEKLAQQLS
IEVVQAHPNG QTASFYAKTT QNHHIAMLVK EKDGNISFDI KSPQSLLNQI LVKEIAQLTF
SSK
