ID   AP3M1_CHICK             Reviewed;         418 AA.
AC   Q5ZMP7;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=AP-3 complex subunit mu-1;
DE   AltName: Full=AP-3 adaptor complex mu3A subunit;
DE   AltName: Full=Adaptor-related protein complex 3 subunit mu-1;
DE   AltName: Full=Mu-adaptin 3A;
DE   AltName: Full=Mu3A-adaptin;
GN   Name=AP3M1; ORFNames=RCJMB04_1h22;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC       not clathrin-associated. The complex is associated with the Golgi
CC       region as well as more peripheral structures. It facilitates the
CC       budding of vesicles from the Golgi membrane and may be directly
CC       involved in trafficking to lysosomes. In concert with the BLOC-1
CC       complex, AP-3 is required to target cargos into vesicles assembled at
CC       cell bodies for delivery into neurites and nerve terminals (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: The AP-3 complex associates with the BLOC-1 complex.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasmic
CC       vesicle membrane {ECO:0000250}; Peripheral membrane protein
CC       {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Component of the
CC       coat surrounding the cytoplasmic face of coated vesicles located at the
CC       Golgi complex. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC       {ECO:0000305}.
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DR   EMBL; AJ719337; CAG30996.1; -; mRNA.
DR   RefSeq; NP_001026398.1; NM_001031227.1.
DR   AlphaFoldDB; Q5ZMP7; -.
DR   SMR; Q5ZMP7; -.
DR   STRING; 9031.ENSGALP00000008112; -.
DR   PaxDb; Q5ZMP7; -.
DR   GeneID; 423736; -.
DR   KEGG; gga:423736; -.
DR   CTD; 26985; -.
DR   VEuPathDB; HostDB:geneid_423736; -.
DR   eggNOG; KOG2740; Eukaryota.
DR   InParanoid; Q5ZMP7; -.
DR   OrthoDB; 928391at2759; -.
DR   PhylomeDB; Q5ZMP7; -.
DR   PRO; PR:Q5ZMP7; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IBA:GO_Central.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR001392; Clathrin_mu.
DR   InterPro; IPR018240; Clathrin_mu_CS.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   InterPro; IPR028565; MHD.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF005992; Clathrin_mu; 1.
DR   PRINTS; PR00314; CLATHRINADPT.
DR   SUPFAM; SSF49447; SSF49447; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS00990; CLAT_ADAPTOR_M_1; 1.
DR   PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..418
FT                   /note="AP-3 complex subunit mu-1"
FT                   /id="PRO_0000285806"
FT   DOMAIN          176..417
FT                   /note="MHD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00404"
SQ   SEQUENCE   418 AA;  46972 MW;  6C61E445A06B2FE5 CRC64;
     MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAI DVENVPPVIS TPLHYLISIY
     RDKIFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSET AIKDNVVIVY ELLEEMLDNG
     FPLATESNIL KELIKPPTIL RSVVNSITGS SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY
     FDVIEEIDAI IDKSGSTVFA EIQGVIDSCI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK
     RWESERVLSF IPPDGNFRLI SYRVSSQNLV AIPVYVKHLI SFKENSSSGR FDVTIGPKQN
     MGKTVEGVVM TVHMPKAVLN MNLTATQGSY TFDPVTKVLA WDVGKITPQK LPNLKGIVNL
     QSGAPKPEEN PSLNIQFKIQ QLAISGLKVN RLDMYGEKYK PFKGVKYITK AGKFQVRT