ID   AP3S2_BOVIN             Reviewed;         193 AA.
AC   Q1JQA3;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=AP-3 complex subunit sigma-2;
DE   AltName: Full=AP-3 complex subunit sigma-3B;
DE   AltName: Full=Adaptor-related protein complex 3 subunit sigma-2;
DE   AltName: Full=Sigma-3B-adaptin;
DE            Short=Sigma3B-adaptin;
DE   AltName: Full=Sigma-adaptin 3b;
GN   Name=AP3S2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC       not clathrin-associated. The complex is associated with the Golgi
CC       region as well as more peripheral structures. It facilitates the
CC       budding of vesicles from the Golgi membrane and may be directly
CC       involved in trafficking to lysosomes. In concert with the BLOC-1
CC       complex, AP-3 is required to target cargos into vesicles assembled at
CC       cell bodies for delivery into neurites and nerve terminals (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC       of two large adaptins (delta-type subunit AP3D1 and beta-type subunit
CC       AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and
CC       a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with
CC       AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Note=Component of the coat surrounding the
CC       cytoplasmic face of coated vesicles located at the Golgi complex.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; BC116115; AAI16116.1; -; mRNA.
DR   RefSeq; NP_001068844.1; NM_001075376.1.
DR   AlphaFoldDB; Q1JQA3; -.
DR   SMR; Q1JQA3; -.
DR   STRING; 9913.ENSBTAP00000001846; -.
DR   BindingDB; Q1JQA3; -.
DR   PaxDb; Q1JQA3; -.
DR   PRIDE; Q1JQA3; -.
DR   Ensembl; ENSBTAT00000001846; ENSBTAP00000001846; ENSBTAG00000001407.
DR   GeneID; 508867; -.
DR   KEGG; bta:508867; -.
DR   CTD; 10239; -.
DR   VEuPathDB; HostDB:ENSBTAG00000001407; -.
DR   VGNC; VGNC:53932; AP3S2.
DR   eggNOG; KOG0936; Eukaryota.
DR   GeneTree; ENSGT00970000193421; -.
DR   HOGENOM; CLU_061221_2_2_1; -.
DR   InParanoid; Q1JQA3; -.
DR   OMA; DLIFNWQ; -.
DR   OrthoDB; 1458249at2759; -.
DR   TreeFam; TF300189; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000001407; Expressed in choroid plexus and 106 other tissues.
DR   GO; GO:0030123; C:AP-3 adaptor complex; IEA:Ensembl.
DR   GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0008089; P:anterograde axonal transport; ISS:UniProtKB.
DR   GO; GO:0048490; P:anterograde synaptic vesicle transport; ISS:UniProtKB.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14834; AP3_sigma; 1.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR027155; APS3.
DR   InterPro; IPR000804; Clathrin_sm-chain_CS.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
DR   PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..193
FT                   /note="AP-3 complex subunit sigma-2"
FT                   /id="PRO_0000283806"
SQ   SEQUENCE   193 AA;  22035 MW;  D219EF4A9FFED6EA CRC64;
     MIQAILVFNN HGKPRLVRFY QRFPEEIQQQ IVRETFHLVL KRDDNICNFL EGGSLIGGSD
     YKLIYRHYAT LYFVFCVDSS ESELGILDLI QVFVETLDKC FENVCELDLI FHMDKVHYIL
     QEVVMGGMVL ETNMNEIVAQ IEAQNRLEKS EGGLSAAPAR AVSAVKNINL PEMPRNINIG
     DLNIKVPNLS QFV