AP3S_ASHGO
ID AP3S_ASHGO Reviewed; 185 AA.
AC Q75F71;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=AP-3 complex subunit sigma;
DE AltName: Full=AP-3 complex sigma3A subunit;
DE AltName: Full=Adaptor-related protein complex 3 subunit sigma;
DE AltName: Full=Clathrin-associated/assembly/adaptor protein, small 3;
DE AltName: Full=Sigma-adaptin 3A;
DE AltName: Full=Sigma3-adaptin;
GN Name=APS3; OrderedLocusNames=AAL143W;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane and may be directly
CC involved in trafficking to the vacuole (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a
CC small adaptin (APS3). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:P47064}.
CC Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P47064}; Peripheral
CC membrane protein {ECO:0000250|UniProtKB:P47064}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P47064}. Note=Component of the coat surrounding
CC the cytoplasmic face of coated vesicles located at the Golgi complex.
CC {ECO:0000250|UniProtKB:P47064}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE016814; AAS50223.1; -; Genomic_DNA.
DR RefSeq; NP_982399.1; NM_207752.1.
DR AlphaFoldDB; Q75F71; -.
DR SMR; Q75F71; -.
DR STRING; 33169.AAS50223; -.
DR EnsemblFungi; AAS50223; AAS50223; AGOS_AAL143W.
DR GeneID; 4618593; -.
DR KEGG; ago:AGOS_AAL143W; -.
DR eggNOG; KOG0936; Eukaryota.
DR HOGENOM; CLU_061221_2_2_1; -.
DR InParanoid; Q75F71; -.
DR OMA; DLIFNWQ; -.
DR Proteomes; UP000000591; Chromosome I.
DR GO; GO:0030123; C:AP-3 adaptor complex; IEA:EnsemblFungi.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IEA:EnsemblFungi.
DR GO; GO:0006623; P:protein targeting to vacuole; IEA:EnsemblFungi.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; PTHR11753; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..185
FT /note="AP-3 complex subunit sigma"
FT /id="PRO_0000227679"
SQ SEQUENCE 185 AA; 21048 MW; 36ECEDDA5A2127E9 CRC64;
MIHAVLIFNK KCQPRLVKYY TPVDLPKQKL LLEQVYELIS QRNSSIQSSF LITPPSLLSS
GSETINEDIQ IIYKNYATLY FTFIVDDQES ELAILDLIQT FVEALDRCFA EVNELDLIFN
WQTLESVLEE IIQGGMVIET NVKKIVETVD ELNRTSNQEA RFGNGLGNAF QAITMGGFSN
WGARQ
