ID   AP3S_DICDI              Reviewed;         171 AA.
AC   Q553S2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=AP-3 complex subunit sigma;
DE   AltName: Full=AP-3 complex subunit sigma-3;
DE   AltName: Full=Adaptor-related protein complex 3 subunit sigma;
DE   AltName: Full=Sigma-adaptin 3;
DE   AltName: Full=Sigma3-adaptin;
GN   Name=ap3s1; ORFNames=DDB_G0275405;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC       essential for the compartmentalization of the endocytic pathway.
CC   -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC       of two large adaptins (delta-type subunit and beta-type subunit), a
CC       medium adaptin (mu-type subunit) and a small adaptin (sigma-type
CC       subunit). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AAFI02000013; EAL69768.1; -; Genomic_DNA.
DR   RefSeq; XP_643675.1; XM_638583.1.
DR   AlphaFoldDB; Q553S2; -.
DR   SMR; Q553S2; -.
DR   STRING; 44689.DDB0234244; -.
DR   PaxDb; Q553S2; -.
DR   EnsemblProtists; EAL69768; EAL69768; DDB_G0275405.
DR   GeneID; 8619941; -.
DR   KEGG; ddi:DDB_G0275405; -.
DR   dictyBase; DDB_G0275405; ap3s1.
DR   eggNOG; KOG0936; Eukaryota.
DR   HOGENOM; CLU_061221_2_2_1; -.
DR   InParanoid; Q553S2; -.
DR   OMA; DLIFNWQ; -.
DR   PhylomeDB; Q553S2; -.
DR   PRO; PR:Q553S2; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   CDD; cd14834; AP3_sigma; 1.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR027155; APS3.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   3: Inferred from homology;
KW   Endosome; Membrane; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..171
FT                   /note="AP-3 complex subunit sigma"
FT                   /id="PRO_0000328680"
SQ   SEQUENCE   171 AA;  19940 MW;  6FD3088987DEA615 CRC64;
     MIKSILIINN HGKPRLIKFY EHYSEEKQQQ IIRELFLLVS KRTERSCNFL EIGNNSNIFD
     KDTKIIYRHY ATLFFIFCVD SSESELSIID LIQTFVESLD KCFENVCELD LIFHIDKVHY
     ILDEMVMGGL VLETNPTIIF SNYEIQNKLE KAENPLLSGL AGVMQTIKPN K