AP3S_SCHPO
ID AP3S_SCHPO Reviewed; 165 AA.
AC Q09905;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 25-MAY-2022, entry version 132.
DE RecName: Full=AP-3 complex subunit sigma;
DE AltName: Full=AP-3 complex sigma3A subunit;
DE AltName: Full=Adaptor-related protein complex 3 subunit sigma;
DE AltName: Full=Clathrin-associated/assembly/adaptor protein, small 3;
DE AltName: Full=Sigma-adaptin 3A;
DE AltName: Full=Sigma3-adaptin;
GN Name=aps3; ORFNames=SPAC30D11.05;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane and may be directly
CC involved in trafficking to the vacuole (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Adaptor protein complex 3 (AP-3) is a heterotetramer composed
CC of 2 large adaptins (apl5 and apl6), a medium adaptin (apm3) and a
CC small adaptin (aps3). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:P47064}.
CC Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P47064}; Peripheral
CC membrane protein {ECO:0000250|UniProtKB:P47064}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:P47064}. Note=Component of the coat surrounding
CC the cytoplasmic face of coated vesicles located at the Golgi complex.
CC {ECO:0000250|UniProtKB:P47064}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000305}.
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DR EMBL; CU329670; CAA91891.1; -; Genomic_DNA.
DR PIR; T38594; S62563.
DR RefSeq; NP_593212.1; NM_001018608.2.
DR AlphaFoldDB; Q09905; -.
DR SMR; Q09905; -.
DR BioGRID; 278590; 2.
DR STRING; 4896.SPAC30D11.05.1; -.
DR MaxQB; Q09905; -.
DR PaxDb; Q09905; -.
DR EnsemblFungi; SPAC30D11.05.1; SPAC30D11.05.1:pep; SPAC30D11.05.
DR GeneID; 2542114; -.
DR KEGG; spo:SPAC30D11.05; -.
DR PomBase; SPAC30D11.05; aps3.
DR VEuPathDB; FungiDB:SPAC30D11.05; -.
DR eggNOG; KOG0936; Eukaryota.
DR HOGENOM; CLU_061221_2_2_1; -.
DR InParanoid; Q09905; -.
DR OMA; DLIFNWQ; -.
DR PhylomeDB; Q09905; -.
DR PRO; PR:Q09905; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0030123; C:AP-3 adaptor complex; ISO:PomBase.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0006896; P:Golgi to vacuole transport; ISO:PomBase.
DR GO; GO:0006886; P:intracellular protein transport; IC:PomBase.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; PTHR11753; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle; Golgi apparatus; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..165
FT /note="AP-3 complex subunit sigma"
FT /id="PRO_0000193823"
SQ SEQUENCE 165 AA; 18643 MW; 9EA796AD34C40FF3 CRC64;
MIYAVFIFNN KGKPRLTKFY TPIDESIQQK LIGDIYAAVS TRPPTACNFL ESNLIAGKNR
IIYRQYATLY FVFVVDEGES ELGILDLIQV FVEALDRCFN NVCELDLVFK FQEIHAILAE
VVSGGLVLET NLNEIVLAAQ NQMPKTKRSN AMPFSNTLSS FATRF
