3SX4_MICMP
ID 3SX4_MICMP Reviewed; 82 AA.
AC A0A2P1BSS8;
DT 12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 1.
DT 25-MAY-2022, entry version 10.
DE RecName: Full=Mipartoxin-4 {ECO:0000305};
DE AltName: Full=Mipartoxin-IV {ECO:0000303|PubMed:31557485};
DE AltName: Full=Three-finger toxin-05 {ECO:0000303|PubMed:31557485};
DE Short=3FTx-05 {ECO:0000303|PubMed:31557485};
DE Flags: Precursor;
OS Micrurus mipartitus (Red-tailed coral snake).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Elapidae; Elapinae; Micrurus.
OX NCBI_TaxID=430902 {ECO:0000312|EMBL:AVI57323.1};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Venom gland {ECO:0000303|PubMed:31557485};
RX PubMed=31557485; DOI=10.1016/j.toxicon.2019.09.017;
RA Rey-Suarez P., Saldarriaga-Cordoba M., Torres U., Marin-Villa M.,
RA Lomonte B., Nunez V.;
RT "Novel three-finger toxins from Micrurus dumerilii and Micrurus mipartitus
RT coral snake venoms: Phylogenetic relationships and characterization of
RT Clarkitoxin-I-Mdum.";
RL Toxicon 170:85-93(2019).
CC -!- FUNCTION: Snake venom neurotoxin that blocks neuromuscular
CC transmission, presenting a postsynaptic action through the nicotinic
CC acetylcholine receptor (nAChR). Has no cytotoxic activity.
CC {ECO:0000250|UniProtKB:B3EWF8}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:B3EWF8}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000269|PubMed:31557485}.
CC -!- SIMILARITY: Belongs to the snake three-finger toxin family. Short-chain
CC subfamily. {ECO:0000305}.
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DR EMBL; KY635904; AVI57323.1; -; mRNA.
DR AlphaFoldDB; A0A2P1BSS8; -.
DR SMR; A0A2P1BSS8; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR CDD; cd00206; snake_toxin; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR003571; Snake_3FTx.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR018354; Snake_toxin_con_site.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00272; SNAKE_TOXIN; 1.
PE 2: Evidence at transcript level;
KW Acetylcholine receptor inhibiting toxin; Disulfide bond;
KW Ion channel impairing toxin; Neurotoxin; Postsynaptic neurotoxin; Secreted;
KW Signal; Toxin.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..82
FT /note="Mipartoxin-4"
FT /evidence="ECO:0000255"
FT /id="PRO_5015202845"
FT DISULFID 24..45
FT /evidence="ECO:0000250|UniProtKB:P07526"
FT DISULFID 38..59
FT /evidence="ECO:0000250|UniProtKB:P07526"
FT DISULFID 63..74
FT /evidence="ECO:0000250|UniProtKB:P07526"
FT DISULFID 75..80
FT /evidence="ECO:0000250|UniProtKB:P07526"
SQ SEQUENCE 82 AA; 9165 MW; 35C893E13A29D921 CRC64;
MKTLLLTLVV VTIVCLDLGY TRKCHTKNSP GRETSQACPT GQNICFKKWK KGEIISKGCA
VTCPKPKKDE TFQCCLKNNC NR