AP4B_DICDI
ID AP4B_DICDI Reviewed; 838 AA.
AC Q54R84;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=AP-4 complex subunit beta {ECO:0000305};
DE AltName: Full=AP-4 adaptor complex subunit beta;
DE AltName: Full=Adaptor-related protein complex 4 subunit beta;
DE AltName: Full=Beta subunit of AP-4;
DE AltName: Full=Beta4-adaptin;
GN Name=ap4b1 {ECO:0000312|dictyBase:DDB_G0283319};
GN ORFNames=DDB_G0283319 {ECO:0000312|dictyBase:DDB_G0283319};
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable component of an adaptor protein complex. Adaptor
CC protein complexes are vesicle coat components involved both in vesicle
CC formation and cargo selection. They control the vesicular transport of
CC proteins in different trafficking pathways.
CC {ECO:0000250|UniProtKB:Q9Y6B7}.
CC -!- SUBUNIT: May be part of the adaptor protein complex 4 (AP-4), a
CC heterotetramer composed of two large adaptins (epsilon-type subunitand
CC beta-type subunit), a medium adaptin (mu-type subunit) and a small
CC adaptin (sigma-type). {ECO:0000250|UniProtKB:Q9Y6B7}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250|UniProtKB:Q9Y6B7}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q9Y6B7}.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAFI02000052; EAL65800.1; -; Genomic_DNA.
DR RefSeq; XP_639163.1; XM_634071.1.
DR AlphaFoldDB; Q54R84; -.
DR SMR; Q54R84; -.
DR STRING; 44689.DDB0234245; -.
DR PaxDb; Q54R84; -.
DR EnsemblProtists; EAL65800; EAL65800; DDB_G0283319.
DR GeneID; 8624033; -.
DR KEGG; ddi:DDB_G0283319; -.
DR dictyBase; DDB_G0283319; ap4b1.
DR eggNOG; KOG1061; Eukaryota.
DR HOGENOM; CLU_006320_4_5_1; -.
DR InParanoid; Q54R84; -.
DR OMA; ANCMHAL; -.
DR PhylomeDB; Q54R84; -.
DR Reactome; R-DDI-432720; Lysosome Vesicle Biogenesis.
DR PRO; PR:Q54R84; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 1.
DR Gene3D; 3.30.310.10; -; 1.
DR InterPro; IPR026739; AP_beta.
DR InterPro; IPR016342; AP_complex_bsu_1_2_4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR015151; B-adaptin_app_sub_C.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR012295; TBP_dom_sf.
DR PANTHER; PTHR11134; PTHR11134; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF09066; B2-adapt-app_C; 1.
DR PIRSF; PIRSF002291; AP_complex_beta; 1.
DR SMART; SM01020; B2-adapt-app_C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..838
FT /note="AP-4 complex subunit beta"
FT /id="PRO_0000328669"
FT REGION 582..673
FT /note="Hinge"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6B7"
FT REGION 648..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..838
FT /note="Ear"
FT /evidence="ECO:0000250|UniProtKB:Q9Y6B7"
SQ SEQUENCE 838 AA; 96507 MW; FC7279AE2B8A7604 CRC64;
MTSTANYNNS GKDSYFSEIK KSELGLIKNN LSTAINERNA DKIKDILQRI IYYMTIGMDV
SVLFPDVIMV ASSNDIIIKK LVYLYIVHYS KSNPDLLLLV VNTLRRDCID RNPIIRGLAL
RSLCSLDSKN TLEYATIEIN RSLTDFSGYV RKTALLGLAK LYHLSKEAFD LDIIIPKIFD
MIMDQDPQVI VNAVSTLNEI KPGWSFTFDL VQHLMIKFKE FNEWSQCIIL ECLSRYTPSS
EDESLDILNL LDDRLSHSNS ALTLSTIKIF LKYTDEFEEI QEQVYERIKE PLITLMESSE
SNETSFTILH HIHLLMSRSP RLFNRYYKHF YCKFDDPLYI KTLKVQVLKE IASNQTFIES
IDEILQELSE YVYEGDHSLC KQSINAITVI AQKHKNTQEK YPIDESVLEK IFLPYLSVSS
NLGGAGDDNI SINEGILSFI LISLKDFLRV FPKHLKTVLP YINENLIGIG SVSNYTLPPS
ANESVLWMLG ESPNSQVNSP YIIEEFFNEK FDQQPTFVKT QLLTTSLKVF FDRPGEMLPI
LKRILKKCCS DLSQDPGLHE ISLFYSRIIL LLDIDKAASI INSSKQTTSI NTFLEDEINE
YRDKIFDEFN TLSVLFGKHS TKFIKNKKQI ENEKLQFLEN QKNYLLSITD GNQNNNQNNN
QNNNQNNNQN NNQNNQNNNN QNNNSKQLLK EIESSPNNLI DTFILDQQPE LSPELFQSLW
LSLEDGHKID IQLDSPIDNS EIESVMSKQG IICLAFGSVD QQTKLYYYAR QNLSFDIDFN
SEQNQQQPQP IFIIEILIDE NTLLMSILFK SPILKTLHNK FIPKFLSILS IPIPKIFN
