ID   AP4S1_BOVIN             Reviewed;         144 AA.
AC   Q3ZBB6;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=AP-4 complex subunit sigma-1 {ECO:0000305};
DE   AltName: Full=AP-4 adaptor complex subunit sigma-1;
DE   AltName: Full=Adaptor-related protein complex 4 subunit sigma-1;
DE   AltName: Full=Sigma-1 subunit of AP-4;
DE   AltName: Full=Sigma-4-adaptin;
DE            Short=Sigma4-adaptin;
GN   Name=AP4S1 {ECO:0000250|UniProtKB:Q9Y587};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor
CC       protein complexes are vesicle coat components involved both in vesicle
CC       formation and cargo selection. They control the vesicular transport of
CC       proteins in different trafficking pathways. AP-4 forms a non clathrin-
CC       associated coat on vesicles departing the trans-Golgi network (TGN) and
CC       may be involved in the targeting of proteins from the trans-Golgi
CC       network (TGN) to the endosomal-lysosomal system. It is also involved in
CC       protein sorting to the basolateral membrane in epithelial cells and the
CC       proper asymmetric localization of somatodendritic proteins in neurons.
CC       AP-4 is involved in the recognition and binding of tyrosine-based
CC       sorting signals found in the cytoplasmic part of cargos, but may also
CC       recognize other types of sorting signal.
CC       {ECO:0000250|UniProtKB:Q9Y587}.
CC   -!- SUBUNIT: Adaptor protein complex 4 (AP-4) is a heterotetramer composed
CC       of two large adaptins (epsilon-type subunit AP4E1 and beta-type subunit
CC       AP4B1), a medium adaptin (mu-type subunit AP4M1) and a small adaptin
CC       (sigma-type AP4S1). {ECO:0000250|UniProtKB:Q9Y587}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane
CC       {ECO:0000250|UniProtKB:Q9Y587}; Peripheral membrane protein
CC       {ECO:0000250|UniProtKB:Q9Y587}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC       {ECO:0000305}.
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DR   EMBL; BC103455; AAI03456.1; -; mRNA.
DR   RefSeq; NP_001035693.1; NM_001040603.2.
DR   AlphaFoldDB; Q3ZBB6; -.
DR   SMR; Q3ZBB6; -.
DR   STRING; 9913.ENSBTAP00000043387; -.
DR   BindingDB; Q3ZBB6; -.
DR   PaxDb; Q3ZBB6; -.
DR   PRIDE; Q3ZBB6; -.
DR   Ensembl; ENSBTAT00000070758; ENSBTAP00000060856; ENSBTAG00000017201.
DR   GeneID; 618267; -.
DR   KEGG; bta:618267; -.
DR   CTD; 11154; -.
DR   VEuPathDB; HostDB:ENSBTAG00000017201; -.
DR   VGNC; VGNC:25994; AP4S1.
DR   eggNOG; KOG0934; Eukaryota.
DR   GeneTree; ENSGT00970000193421; -.
DR   HOGENOM; CLU_061221_4_0_1; -.
DR   InParanoid; Q3ZBB6; -.
DR   OMA; KDQCSFI; -.
DR   OrthoDB; 1307450at2759; -.
DR   TreeFam; TF331913; -.
DR   Proteomes; UP000009136; Chromosome 21.
DR   Bgee; ENSBTAG00000017201; Expressed in choroid plexus and 104 other tissues.
DR   ExpressionAtlas; Q3ZBB6; baseline and differential.
DR   GO; GO:0030124; C:AP-4 adaptor complex; ISS:UniProtKB.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR016635; AP_complex_ssu.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR011012; Longin-like_dom_sf.
DR   PANTHER; PTHR11753; PTHR11753; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF015588; AP_complex_sigma; 1.
DR   SUPFAM; SSF64356; SSF64356; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..144
FT                   /note="AP-4 complex subunit sigma-1"
FT                   /id="PRO_0000283807"
SQ   SEQUENCE   144 AA;  16991 MW;  0BD3BBFA756C95D1 CRC64;
     MIKFFLMVNK QGQTRLSKYY EHVEINKRTL LETEVIKSCL SRSNEQCSFI EYKDFKLIYR
     QYAALFIVVG VNDTENEMAI YEFIHNFVEV LDDYFSRVSE LDIMFNLDKV HIILDEMVLN
     GCIVETNRAR ILAPLLILDK MSDS