ID   AP5M1_BOVIN             Reviewed;         490 AA.
AC   Q5E9X5;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=AP-5 complex subunit mu-1;
DE   AltName: Full=Adaptor-related protein complex 5 subunit mu-1;
DE            Short=Mu5;
GN   Name=AP5M1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1] {ECO:0000312|EMBL:AAX08812.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it
CC       may be involved in endosomal transport. {ECO:0000250}.
CC   -!- SUBUNIT: Probably part of the adaptor protein complex 5 (AP-5) a
CC       tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Late endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Note=May cycle on and off membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC       {ECO:0000255}.
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DR   EMBL; BT020795; AAX08812.1; -; mRNA.
DR   RefSeq; NP_001015670.1; NM_001015670.1.
DR   AlphaFoldDB; Q5E9X5; -.
DR   SMR; Q5E9X5; -.
DR   STRING; 9913.ENSBTAP00000017337; -.
DR   PaxDb; Q5E9X5; -.
DR   PRIDE; Q5E9X5; -.
DR   Ensembl; ENSBTAT00000017337; ENSBTAP00000017337; ENSBTAG00000013043.
DR   GeneID; 539663; -.
DR   KEGG; bta:539663; -.
DR   CTD; 55745; -.
DR   VEuPathDB; HostDB:ENSBTAG00000013043; -.
DR   VGNC; VGNC:25996; AP5M1.
DR   eggNOG; KOG0937; Eukaryota.
DR   GeneTree; ENSGT00390000006191; -.
DR   HOGENOM; CLU_033295_0_0_1; -.
DR   InParanoid; Q5E9X5; -.
DR   OMA; FFNRNQM; -.
DR   OrthoDB; 395662at2759; -.
DR   TreeFam; TF331963; -.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000013043; Expressed in oocyte and 108 other tissues.
DR   GO; GO:0030119; C:AP-type membrane coat adaptor complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR039591; AP5M1.
DR   InterPro; IPR028565; MHD.
DR   PANTHER; PTHR16082; PTHR16082; 1.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   SUPFAM; SSF49447; SSF49447; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Lysosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..490
FT                   /note="AP-5 complex subunit mu-1"
FT                   /id="PRO_0000374053"
FT   DOMAIN          206..476
FT                   /note="MHD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00404"
SQ   SEQUENCE   490 AA;  54383 MW;  BEF0AA8F6EE104FF CRC64;
     MAQRAVWLIS HESGTPLGGI VKFSRRYPTV EKRAKVFNGA SYVPVPEDGP FLKALLFELR
     LLDDEKDFLE SRDSCSHINK TSIYGVPVGG EELWPVVAFL KNGMIYACVP LVEQTLSPRP
     PLISISGISQ GFELLFGVQD FLSSGQKTDS ELNTKLSQLS DLLLQTCPFG TLLDANLQNS
     LDSINSASVT HLQKQPAWKT GTYKGKPQVS ISITEKVNSM QYDKQEIADT WQVVGVVTCK
     CDLEGSMPNV TISLSLPTNG SPLQDILVHP CVTSLDSAIL TSSSIDAMDD SAFSGPYKFP
     LTPPLESFNL CYYTSQVPVP PILGFYQVKE EEVQLKITVN LKLHESVKNS FEFCEAHIPF
     YNRGPITHVE YKASFGQLEV FREKSLLVWI IGQKFPKSME ISLSGTITFG AKNHEKQPFD
     QICIGGTAYL KLHFRILDYT LTGCYVDQHS VQVFASGKPK ISTYRKLISS DYYIWNSKAP
     APVTYGSLLL