AP5M1_MACFA
ID AP5M1_MACFA Reviewed; 490 AA.
AC Q4R6Q7;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=AP-5 complex subunit mu-1;
DE AltName: Full=Adaptor-related protein complex 5 subunit mu-1;
DE Short=Mu5;
GN Name=AP5M1; ORFNames=QtsA-17389;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1] {ECO:0000312|EMBL:BAE01217.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis {ECO:0000312|EMBL:BAE01217.1};
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it
CC may be involved in endosomal transport. {ECO:0000250}.
CC -!- SUBUNIT: Probably part of the adaptor protein complex 5 (AP-5) a
CC tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Late endosome membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral
CC membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC Note=May cycle on and off membranes. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC {ECO:0000255}.
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DR EMBL; AB169123; BAE01217.1; -; mRNA.
DR RefSeq; NP_001270256.1; NM_001283327.1.
DR AlphaFoldDB; Q4R6Q7; -.
DR SMR; Q4R6Q7; -.
DR STRING; 9541.XP_005561399.1; -.
DR GeneID; 101926437; -.
DR CTD; 55745; -.
DR eggNOG; KOG0937; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0030119; C:AP-type membrane coat adaptor complex; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR InterPro; IPR036168; AP2_Mu_C_sf.
DR InterPro; IPR039591; AP5M1.
DR InterPro; IPR028565; MHD.
DR PANTHER; PTHR16082; PTHR16082; 1.
DR Pfam; PF00928; Adap_comp_sub; 1.
DR SUPFAM; SSF49447; SSF49447; 1.
DR PROSITE; PS51072; MHD; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Endosome; Lysosome; Membrane; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..490
FT /note="AP-5 complex subunit mu-1"
FT /id="PRO_0000374054"
FT DOMAIN 206..476
FT /note="MHD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00404"
SQ SEQUENCE 490 AA; 54792 MW; 845A5D904847B7FE CRC64;
MAQRAVWLIS HEPGTPLCGT VRFSRRYPTV EKRARVFNGA SYVPIPEDGP FLKALLFELR
LLDDDKDFVE SRDSCSRINK TSIYGLLIGG EELWPVVAFL KNDIIYACVP LVEQTLSPRP
PLISVSGVSQ GFEFLFGIQD FLYSGQKNDS ELNTKLSQLP DLLLQACPFG TLLDANLKNS
LDNTNFASVT QPQKQPAWKT GTYKGKPQVS ISITEKVKSM QYDKQGIADT WQVVGTVTCK
CDLEGIMPNV TISLNLPTNG SPLQDILVHP CVTSLDSAIL TSSSIDAMDD SAFSGPYKFP
LTPPLESFNL CYYTSQVPVP PILGFYQLKE EEVQLRITIN LKLHESVKNN FEFCEAHIPF
YNRGPITHLE YKTSFGQLEV FREKSLLIWI IGQKFPKSME ISLSGTVTFG AKSHEKQPFD
PICIGETAYL KLHFRILDYT LTGCYADQHS VQVFASGKPK ISAYRKLISS DYYIWNSKAP
APVTYGSLLL
