ID   AP5M1_RAT               Reviewed;         490 AA.
AC   Q499N2;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=AP-5 complex subunit mu-1;
DE   AltName: Full=Adaptor-related protein complex 5 subunit mu-1;
DE            Short=Mu5;
DE   AltName: Full=Mu-2-related death-inducing protein {ECO:0000250|UniProtKB:Q9H0R1};
DE            Short=MuD {ECO:0000250|UniProtKB:Q9H0R1};
GN   Name=Ap5m1; Synonyms=Mudeng;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1] {ECO:0000312|EMBL:AAH99829.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate {ECO:0000312|EMBL:AAH99829.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it
CC       may be involved in endosomal transport. {ECO:0000250}.
CC   -!- SUBUNIT: Probably part of the adaptor protein complex 5 (AP-5) a
CC       tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol. Late endosome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic
CC       side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral
CC       membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
CC       Note=May cycle on and off membranes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit family.
CC       {ECO:0000255}.
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DR   EMBL; BC099829; AAH99829.1; -; mRNA.
DR   RefSeq; NP_001025207.1; NM_001030036.1.
DR   AlphaFoldDB; Q499N2; -.
DR   STRING; 10116.ENSRNOP00000018972; -.
DR   iPTMnet; Q499N2; -.
DR   PhosphoSitePlus; Q499N2; -.
DR   PaxDb; Q499N2; -.
DR   Ensembl; ENSRNOT00000096073; ENSRNOP00000090061; ENSRNOG00000014148.
DR   GeneID; 305861; -.
DR   KEGG; rno:305861; -.
DR   UCSC; RGD:1308087; rat.
DR   CTD; 55745; -.
DR   RGD; 1308087; Ap5m1.
DR   eggNOG; KOG0937; Eukaryota.
DR   GeneTree; ENSGT00390000006191; -.
DR   HOGENOM; CLU_033295_0_0_1; -.
DR   InParanoid; Q499N2; -.
DR   OMA; FFNRNQM; -.
DR   OrthoDB; 395662at2759; -.
DR   PhylomeDB; Q499N2; -.
DR   TreeFam; TF331963; -.
DR   PRO; PR:Q499N2; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000014148; Expressed in thymus and 18 other tissues.
DR   Genevisible; Q499N2; RN.
DR   GO; GO:0030119; C:AP-type membrane coat adaptor complex; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005770; C:late endosome; ISS:UniProtKB.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005764; C:lysosome; ISS:UniProtKB.
DR   GO; GO:0016020; C:membrane; ISS:UniProtKB.
DR   GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR036168; AP2_Mu_C_sf.
DR   InterPro; IPR039591; AP5M1.
DR   InterPro; IPR028565; MHD.
DR   PANTHER; PTHR16082; PTHR16082; 1.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   SUPFAM; SSF49447; SSF49447; 1.
DR   PROSITE; PS51072; MHD; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Lysosome; Membrane; Protein transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..490
FT                   /note="AP-5 complex subunit mu-1"
FT                   /id="PRO_0000374055"
FT   DOMAIN          206..476
FT                   /note="MHD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00404"
SQ   SEQUENCE   490 AA;  54439 MW;  A91466D47291E3FC CRC64;
     MALRAVWLIR HEPGTPLGGT VKFSRRYPTV EKRAKVFNGM NYVPVPEDGP FLKALLFQLR
     LLDDDKDFVE SRDSCSNINK TSIYGLSVGG EDLWPVIAFL RNDMIYASVP LVEQALSPRP
     PLISISGVSQ GLELLLGVHD FLYSSQKNDT DLHSRLSQLP DLLLQACPLG TLLDANLQNS
     LNSLNFVSVT QPQKQPAWKV GTYKGKAQIS ISITENVKSM QYGKQDIADT WQVVGTVACK
     CDLEGVMPNV TISLNLPTNG SPLQDIIVHP CVTSLDSAIL TSSSIDTVDD SAFSGPYKFP
     FTPPLESFNL CHYTSQVPVP PILGSYHMKE DGAQLKITVN LKLHESVRNN FEICEAHIPF
     YNRGPITHLE YKVSFGQLEV FREKSLLVWI IGQKFPKSME ISLSGTLTFR VQGHNRQPFD
     HICIGSTAYV KLNFRIADYT LTGCYADQHS VQVFASGKPK ISAYRKLISS DYYIWNSKAS
     APVTYASLLP