AP5Z1_MOUSE
ID AP5Z1_MOUSE Reviewed; 807 AA.
AC Q3U829; Q3UJJ0; Q63ZW8; Q8BS06; Q8C488;
DT 28-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=AP-5 complex subunit zeta-1;
DE AltName: Full=Adaptor-related protein complex 5 zeta subunit;
DE Short=Zeta5;
GN Name=Ap5z1; Synonyms=Kiaa0415;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and DBA/2J; TISSUE=Aorta, and Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-378.
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: As part of AP-5, a probable fifth adaptor protein complex it
CC may be involved in endosomal transport. {ECO:0000250}.
CC -!- SUBUNIT: Probably part of the adaptor protein complex 5 (AP-5) a
CC tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. Interacts with
CC ZFYVE26 and SPG11 (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC30747.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK040924; BAC30747.1; ALT_INIT; mRNA.
DR EMBL; AK082759; BAC38605.1; -; mRNA.
DR EMBL; AK146431; BAE27165.1; -; mRNA.
DR EMBL; AK152402; BAE31190.1; -; mRNA.
DR EMBL; BC082786; AAH82786.1; -; mRNA.
DR CCDS; CCDS39361.1; -.
DR RefSeq; NP_766313.2; NM_172725.2.
DR AlphaFoldDB; Q3U829; -.
DR ComplexPortal; CPX-5182; AP-5 Adaptor complex.
DR STRING; 10090.ENSMUSP00000041863; -.
DR iPTMnet; Q3U829; -.
DR PhosphoSitePlus; Q3U829; -.
DR EPD; Q3U829; -.
DR MaxQB; Q3U829; -.
DR PaxDb; Q3U829; -.
DR PeptideAtlas; Q3U829; -.
DR PRIDE; Q3U829; -.
DR ProteomicsDB; 281789; -.
DR Antibodypedia; 48203; 75 antibodies from 17 providers.
DR DNASU; 231855; -.
DR Ensembl; ENSMUST00000038699; ENSMUSP00000041863; ENSMUSG00000039623.
DR GeneID; 231855; -.
DR KEGG; mmu:231855; -.
DR UCSC; uc009aiq.1; mouse.
DR CTD; 9907; -.
DR MGI; MGI:1924908; Ap5z1.
DR VEuPathDB; HostDB:ENSMUSG00000039623; -.
DR eggNOG; ENOG502QVBK; Eukaryota.
DR GeneTree; ENSGT00390000017592; -.
DR InParanoid; Q3U829; -.
DR OMA; GQHYTED; -.
DR OrthoDB; 414014at2759; -.
DR PhylomeDB; Q3U829; -.
DR TreeFam; TF331050; -.
DR BioGRID-ORCS; 231855; 3 hits in 110 CRISPR screens.
DR ChiTaRS; Ap5z1; mouse.
DR PRO; PR:Q3U829; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q3U829; protein.
DR Bgee; ENSMUSG00000039623; Expressed in ear vesicle and 168 other tissues.
DR ExpressionAtlas; Q3U829; baseline and differential.
DR Genevisible; Q3U829; MM.
DR GO; GO:0044599; C:AP-5 adaptor complex; IC:ComplexPortal.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005770; C:late endosome; IC:ComplexPortal.
DR GO; GO:0016607; C:nuclear speck; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; ISS:UniProtKB.
DR GO; GO:0016197; P:endosomal transport; ISS:UniProtKB.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IC:ComplexPortal.
DR InterPro; IPR028222; AP5Z1.
DR InterPro; IPR016024; ARM-type_fold.
DR PANTHER; PTHR46488; PTHR46488; 1.
DR Pfam; PF14764; SPG48; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA damage; DNA repair; Nucleus; Protein transport;
KW Reference proteome; Transport.
FT CHAIN 1..807
FT /note="AP-5 complex subunit zeta-1"
FT /id="PRO_0000261358"
FT CONFLICT 323
FT /note="C -> G (in Ref. 2; AAH82786)"
FT /evidence="ECO:0000305"
FT CONFLICT 338
FT /note="D -> N (in Ref. 1; BAC30747)"
FT /evidence="ECO:0000305"
FT CONFLICT 428
FT /note="L -> I (in Ref. 1; BAE27165)"
FT /evidence="ECO:0000305"
FT CONFLICT 558
FT /note="V -> I (in Ref. 1; BAC38605)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 807 AA; 89407 MW; DAFDB2B325A0FA40 CRC64;
MFSAGAESLL HQAREIQDEE LRRFCSRVTK LLQEAPGPAT VDALQRLFLI VSATKYPRRL
EKMCVDLLQT TLCLPASPEQ LQVLCAAILR EMSPFNDLAL SCDHTPNTRQ LSLVASVLLA
QGDRKGEIRC VSQRIFKILE NRQPEGPSVR PLLPILSKVI GLAPGILMED QTNLLSKRLV
DWLRYASIQQ GLPYSGGFFS TPRTRQPGPI TEVDGAVASD FFTVLSTGQH FTEDQWVNMQ
AFSMLRKWLL HSGPEDPCSP DADDKSELEG STLSVLSAAS TASRLLPPRE RLREVAFEYC
QRLLEQSNRR ALRKGDSDLQ KACLVEAVSV LDVLCRQDPS FLYRTLSCLK ALHRRLGEDP
GSERALVPLA QFFLNHGEAA AMDAEAVYGQ LLRGLPSERF HSPTLAFEVI HFCTHNLALF
DSHFLSLLRL SFPSLFKFLA WNSPPLTAEF VVLLPALVDA GTAVEMLHAL LDLPCLTAAL
DLQLRSTQTP SERLLWDISL RVPSCLEAFQ DPQFQGLFRH LLRTKASGST ERLTPLHQVL
KPMASCARVT QCAEAVPVLL QAFFSAVTQT ADGALINQLA LLLLERSDSL YPVPQYEARV
HGVLSSQLLV LCKLKPSLVV ELSRELLEFV GSVSSIHSRA SVFTCVVWAI GEYLSVTWDK
RCTAEQINKF FEALEALLFE VTQSRPLADL PCCPPEVVTA LMTTLTKLAS RSQDLIPRVS
LFLSKMRTLA QNPATSSVHS EEGAESIRTR ASELLTLLKM PSVAQFVFTP PAGVCQPRYH
RDTNVALPLA LRTVSRLVEK EAGLLPG
