ID   APA12_ONCMY             Reviewed;         262 AA.
AC   O57524;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Apolipoprotein A-I-2;
DE            Short=Apo-AI-2;
DE            Short=ApoA-I-2;
DE   AltName: Full=Apolipoprotein A1-2;
DE   Contains:
DE     RecName: Full=Proapolipoprotein A-I-2;
DE              Short=ProapoA-I-2;
DE   Flags: Precursor;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Shasta; TISSUE=Liver;
RX   PubMed=1569377;
RA   Delcuve G.P., Sun J.M., Davie J.R.;
RT   "Expression of rainbow trout apolipoprotein A-I genes in liver and
RT   hepatocellular carcinoma.";
RL   J. Lipid Res. 33:251-262(1992).
CC   -!- FUNCTION: Participates in the reverse transport of cholesterol from
CC       tissues to the liver for excretion by promoting cholesterol efflux from
CC       tissues and by acting as a cofactor for the lecithin cholesterol
CC       acyltransferase (LCAT). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the apolipoprotein A1/A4/E family.
CC       {ECO:0000305}.
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DR   EMBL; AF042219; AAB96973.1; -; mRNA.
DR   RefSeq; NP_001117720.1; NM_001124248.1.
DR   AlphaFoldDB; O57524; -.
DR   SMR; O57524; -.
DR   Ensembl; ENSOMYT00000073119; ENSOMYP00000067141; ENSOMYG00000031108.
DR   GeneID; 100135865; -.
DR   KEGG; omy:100135865; -.
DR   CTD; 100135865; -.
DR   GeneTree; ENSGT00950000182929; -.
DR   OrthoDB; 1553412at2759; -.
DR   GO; GO:0034364; C:high-density lipoprotein particle; IEA:UniProtKB-KW.
DR   GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   GO; GO:0042157; P:lipoprotein metabolic process; IEA:InterPro.
DR   InterPro; IPR000074; ApoA_E.
DR   Pfam; PF01442; Apolipoprotein; 1.
PE   2: Evidence at transcript level;
KW   Cholesterol metabolism; HDL; Lipid metabolism; Lipid transport; Repeat;
KW   Secreted; Signal; Steroid metabolism; Sterol metabolism; Transport.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..262
FT                   /note="Proapolipoprotein A-I-2"
FT                   /id="PRO_0000425345"
FT   CHAIN           24..262
FT                   /note="Apolipoprotein A-I-2"
FT                   /id="PRO_0000001968"
FT   REPEAT          64..85
FT                   /note="1"
FT   REPEAT          87..107
FT                   /note="2"
FT   REPEAT          108..118
FT                   /note="3; half-length"
FT   REPEAT          119..140
FT                   /note="4"
FT   REPEAT          141..162
FT                   /note="5"
FT   REPEAT          163..184
FT                   /note="6"
FT   REPEAT          185..206
FT                   /note="7"
FT   REPEAT          207..228
FT                   /note="8"
FT   REPEAT          229..239
FT                   /note="9; half-length"
FT   REPEAT          240..262
FT                   /note="10"
FT   REGION          32..63
FT                   /note="3 X approximate tandem repeats"
FT   REGION          64..262
FT                   /note="10 X approximate tandem repeats"
SQ   SEQUENCE   262 AA;  29680 MW;  234213D38B511A64 CRC64;
     MQFLALALTI LLAAATQAVP MQADAPSQLE HVKVAMMEYM AQVKETAQRS IDHLDDTEYK
     EYKVQLSQSL DNLQQYAQTA SESLAPYSEA IGVQLTEATA AVRAEVMKDV EELRSQLEPK
     RAELKEVLDK HIDEYRKRLE PLIKDIVEQR RTELEAFRVK IEPVVEEMRA KVSANVEETK
     AKLMPIVETV RAKLTERLEE LRTLASPYAE EYKEQMVKAV GEVREKVVPL TTDFKGQLGP
     AAEQAKEKLM ALYETISQAM KA