ID   HSM3_ASHGO              Reviewed;         475 AA.
AC   Q758E4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=DNA mismatch repair protein HSM3;
GN   Name=HSM3; OrderedLocusNames=AEL182W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in DNA mismatch repair in slow-growing cells. Acts
CC       as a chaperone during the assembly of the 26S proteasome, specifically
CC       of the base subcomplex of the 19S regulatory complex (RC) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5B/HSM3 family.
CC       {ECO:0000305}.
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DR   EMBL; AE016818; AAS52503.1; -; Genomic_DNA.
DR   RefSeq; NP_984679.1; NM_210032.1.
DR   AlphaFoldDB; Q758E4; -.
DR   SMR; Q758E4; -.
DR   STRING; 33169.AAS52503; -.
DR   EnsemblFungi; AAS52503; AAS52503; AGOS_AEL182W.
DR   GeneID; 4620864; -.
DR   KEGG; ago:AGOS_AEL182W; -.
DR   eggNOG; ENOG502QWEK; Eukaryota.
DR   HOGENOM; CLU_044760_0_0_1; -.
DR   InParanoid; Q758E4; -.
DR   OMA; YMEQMVL; -.
DR   Proteomes; UP000000591; Chromosome V.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0006298; P:mismatch repair; IEA:EnsemblFungi.
DR   GO; GO:0070682; P:proteasome regulatory particle assembly; IEA:EnsemblFungi.
DR   InterPro; IPR040752; HSM3_C.
DR   InterPro; IPR041335; HSM3_N.
DR   Pfam; PF18794; HSM3_C; 1.
DR   Pfam; PF18795; HSM3_N; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..475
FT                   /note="DNA mismatch repair protein HSM3"
FT                   /id="PRO_0000301755"
SQ   SEQUENCE   475 AA;  54462 MW;  E8884BD6520EB426 CRC64;
     MEEWRIQDRM SQLADVLEAP EEHGVGSVNG LVDMLQLDLG VMVRLDADAR PLLSAMKKVL
     TAGEMSGLDY SGLLSLLDTV VKLAPFETVL EVFSVEDIIT ALESDDQLVR TSCKVLAVSH
     PKDLFSTTRI MDVLLQLYFS QRTVPVNAVE DVFQSLCTDG LIRRRILENN YPLLREMRST
     HDAILFSRYL VLMTILFRHI DRSEFQKELF VPTTEEVLDS LKKDIFLFIN VAKYYRALLE
     YATDPGAAGG PRDWALSYIL PVLHAFGHIY ENKEKYIEVH SYARAYLFQL LRTVSYLEDM
     EVFRELDVKY LHISGDNPDV MHFMAIFNPM YLYRHHFDLL TSQVTVKPSF LPVLKNIVSC
     QETFEILKPA LTASAILIMP YSEQMVLLGQ LSSYPHSTEY LVQELPKVMS NLICNENGPI
     SEPETIELRK KVFENLLLYS ATVLNVWYEP LLDEYTNICS GKTSFVRTEV VDMYL