ID   HSM3_CANAL              Reviewed;         472 AA.
AC   Q59PP0; A0A1D8PRC0; Q3MP11;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein HSM3;
GN   Name=HSM3; OrderedLocusNames=CAALFM_C703450CA;
GN   ORFNames=CaJ7.0396, CaO19.1331, CaO19.8911;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15937140; DOI=10.1534/genetics.104.034652;
RA   Chibana H., Oka N., Nakayama H., Aoyama T., Magee B.B., Magee P.T.,
RA   Mikami Y.;
RT   "Sequence finishing and gene mapping for Candida albicans chromosome 7 and
RT   syntenic analysis against the Saccharomyces cerevisiae genome.";
RL   Genetics 170:1525-1537(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Involved in DNA mismatch repair in slow-growing cells. Acts
CC       as a chaperone during the assembly of the 26S proteasome, specifically
CC       of the base subcomplex of the 19S regulatory complex (RC) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5B/HSM3 family.
CC       {ECO:0000305}.
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DR   EMBL; AP006852; BAE44849.1; -; Genomic_DNA.
DR   EMBL; CP017629; AOW30688.1; -; Genomic_DNA.
DR   RefSeq; XP_711671.1; XM_706579.1.
DR   AlphaFoldDB; Q59PP0; -.
DR   SMR; Q59PP0; -.
DR   BioGRID; 1229806; 1.
DR   STRING; 237561.Q59PP0; -.
DR   GeneID; 3646713; -.
DR   KEGG; cal:CAALFM_C703450CA; -.
DR   CGD; CAL0000181303; HSM3.
DR   VEuPathDB; FungiDB:C7_03450C_A; -.
DR   eggNOG; ENOG502QWEK; Eukaryota.
DR   HOGENOM; CLU_577450_0_0_1; -.
DR   InParanoid; Q59PP0; -.
DR   OMA; YMEQMVL; -.
DR   OrthoDB; 1252574at2759; -.
DR   Proteomes; UP000000559; Chromosome 7.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR040752; HSM3_C.
DR   InterPro; IPR041335; HSM3_N.
DR   Pfam; PF18794; HSM3_C; 1.
DR   Pfam; PF18795; HSM3_N; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..472
FT                   /note="DNA mismatch repair protein HSM3"
FT                   /id="PRO_0000301756"
SQ   SEQUENCE   472 AA;  55468 MW;  4AF2A1C40A06483D CRC64;
     MLDELSYKVL TNLETSYERK QPLGSKLIDR YTLTIDQSTV AQQSYFEQII PAINRILMNS
     EAHVIDPDNV LIRLLPEILS HLSFEQILMY YPNDFILHFL FEEKLENVSV ICLEVILLNL
     QEPETLQFLR DNNVISRLLR EVYFKKTPIS VLNKIERLIT VLNGIEEINL LESCLPILKK
     IRDQGNTVLL SRYLDLVNLL LRYLPEFSPH LYSFTKQEFL KYQDDPLFLI LLIQFYVKLV
     RLKAPVDLSL PLSDILSLYD KFDLLVKNEV VELVAQLSFT QSYTDILFKS QIFKTHNLLE
     VFEKTENSDI RLLSKANPQV IYELNNSIYP DVLAHLNLFT NNLYFPILLN FMSSTTIFYQ
     LKLHLNNEKL SQLPMDKLFK LLLEMSTHNH SKEHLFNNLP TIMSTNLLET EDLRNNELWN
     LKLEILQNLL NDDSVPGFEF WHQELTRNYE LMTFGRVFRN AAPRVDIIDE TA