ID   HSM3_CANGA              Reviewed;         481 AA.
AC   Q6FQ36;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=DNA mismatch repair protein HSM3;
GN   Name=HSM3; OrderedLocusNames=CAGL0I09460g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in DNA mismatch repair in slow-growing cells. Acts
CC       as a chaperone during the assembly of the 26S proteasome, specifically
CC       of the base subcomplex of the 19S regulatory complex (RC) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5B/HSM3 family.
CC       {ECO:0000305}.
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DR   EMBL; CR380955; CAG60595.1; -; Genomic_DNA.
DR   RefSeq; XP_447658.1; XM_447658.1.
DR   AlphaFoldDB; Q6FQ36; -.
DR   SMR; Q6FQ36; -.
DR   STRING; 5478.XP_447658.1; -.
DR   EnsemblFungi; CAG60595; CAG60595; CAGL0I09460g.
DR   GeneID; 2888931; -.
DR   KEGG; cgr:CAGL0I09460g; -.
DR   CGD; CAL0132546; CAGL0I09460g.
DR   VEuPathDB; FungiDB:CAGL0I09460g; -.
DR   eggNOG; ENOG502QWEK; Eukaryota.
DR   HOGENOM; CLU_044760_0_0_1; -.
DR   InParanoid; Q6FQ36; -.
DR   OMA; YMEQMVL; -.
DR   Proteomes; UP000002428; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0006298; P:mismatch repair; IEA:EnsemblFungi.
DR   GO; GO:0070682; P:proteasome regulatory particle assembly; IEA:EnsemblFungi.
DR   InterPro; IPR040752; HSM3_C.
DR   InterPro; IPR041335; HSM3_N.
DR   Pfam; PF18794; HSM3_C; 1.
DR   Pfam; PF18795; HSM3_N; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..481
FT                   /note="DNA mismatch repair protein HSM3"
FT                   /id="PRO_0000301757"
SQ   SEQUENCE   481 AA;  55648 MW;  BCB88838D5FD0E43 CRC64;
     MEQVFLEINE KLPGLLTTGG SDATFAESSK LIERCNLALI SFTGTPTAVM DDTIKLMKSI
     LASNESYNID YDQLMDLMSQ MVIKYPFDRI LELFTVEELA LALNSPIERL NIMTCVVVEY
     SEPSGLFAST TLIDILLQKY LDEDSSVNLV NSIEKVWKKT AQDELIRRRI LENNYNFLSE
     VKNNEPNSLV FTRLLELLKI CFTYLKSTEF RNSLFLISKK MIMDAVKDNI LVFISICEYF
     TSIFSIVQDQ KSQNPSKIIC VRNCENTIML FGDLFQNRSE FPDIEQFALS YLFKMFKILS
     YFDDLIVFEK LDNGYIHIED GNEYLTDFLS FISPQYLYKK HLNIIKSKGH VRPSEISIIR
     NLCMSSDCFD IIKKNITAED ILAMPYLEQM ILLEKMSQYD YSVKFLAQHL PKVMGSLISK
     DVKELLDRET FDFRLQVINN LIEWDVEQLH IWYEPLTEAK AQCMGTFASK DVGTKIESSF
     S