ID   HSM3_DEBHA              Reviewed;         503 AA.
AC   Q6BU68;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=DNA mismatch repair protein HSM3;
GN   Name=HSM3; OrderedLocusNames=DEHA2C13178g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in DNA mismatch repair in slow-growing cells. Acts
CC       as a chaperone during the assembly of the 26S proteasome, specifically
CC       of the base subcomplex of the 19S regulatory complex (RC) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5B/HSM3 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382135; CAG86327.2; -; Genomic_DNA.
DR   RefSeq; XP_458251.2; XM_458251.1.
DR   AlphaFoldDB; Q6BU68; -.
DR   SMR; Q6BU68; -.
DR   STRING; 4959.XP_458251.2; -.
DR   EnsemblFungi; CAG86327; CAG86327; DEHA2C13178g.
DR   GeneID; 2900084; -.
DR   KEGG; dha:DEHA2C13178g; -.
DR   VEuPathDB; FungiDB:DEHA2C13178g; -.
DR   eggNOG; ENOG502QWEK; Eukaryota.
DR   HOGENOM; CLU_553323_0_0_1; -.
DR   InParanoid; Q6BU68; -.
DR   OMA; YMEQMVL; -.
DR   OrthoDB; 1032018at2759; -.
DR   Proteomes; UP000000599; Chromosome C.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR040752; HSM3_C.
DR   InterPro; IPR041335; HSM3_N.
DR   Pfam; PF18794; HSM3_C; 1.
DR   Pfam; PF18795; HSM3_N; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..503
FT                   /note="DNA mismatch repair protein HSM3"
FT                   /id="PRO_0000301758"
SQ   SEQUENCE   503 AA;  58063 MW;  EB7151CAC162FE3F CRC64;
     MDYNGIDSSS VKTHVHLNEI LNNDKVVNAT LIENYILQLK NNRSIIFPDE QPNGSIGSNK
     FISLFIPTIN SLLNGEHYFE IDPERVVISL LDAILAYLNI EEILSLYPLD FIINGLTGDS
     AICCMIIRLL RNNATSETTV KLFDETAILD TILSRYFEKN TTLNVVSQVE LLISELVDLS
     STVVSTKLLS TEFRDLYEHA RDNEDKLVKF LDYILLLMPY ILEKQFDLPK NYYVLSYSEF
     YENDDVLQVV LFIQFYSKLI QRINTFGNDT NIIHNIKPCL KDLISYFKTR QNDDIVQSFY
     ANDIVDVLFH VSYSKVPELL TFNEEVVGQY ELFKSYNLFL HLDCDIKLLS TFNPRALPLE
     IIEDILQEIS IFNQKYFSIL LNCIGSENVF NKLIPRLTTS VIGKLSFDML YSLLLRMSEF
     EYSRKHLING MPNIVSDYLA NPPNVSESEI WNLKKDTLQN LLFSNTDLNV WHDPISKNFS
     LMCNGRKVQD ILPQVDIADK SLQ