ID   HSM3_KLULA              Reviewed;         469 AA.
AC   Q6CLP9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=DNA mismatch repair protein HSM3;
GN   Name=HSM3; OrderedLocusNames=KLLA0F01342g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in DNA mismatch repair in slow-growing cells. Acts
CC       as a chaperone during the assembly of the 26S proteasome, specifically
CC       of the base subcomplex of the 19S regulatory complex (RC) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5B/HSM3 family.
CC       {ECO:0000305}.
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DR   EMBL; CR382126; CAG97847.1; -; Genomic_DNA.
DR   RefSeq; XP_455140.1; XM_455140.1.
DR   AlphaFoldDB; Q6CLP9; -.
DR   SMR; Q6CLP9; -.
DR   STRING; 28985.XP_455140.1; -.
DR   EnsemblFungi; CAG97847; CAG97847; KLLA0_F01342g.
DR   GeneID; 2896004; -.
DR   KEGG; kla:KLLA0_F01342g; -.
DR   eggNOG; ENOG502QWEK; Eukaryota.
DR   HOGENOM; CLU_044760_0_0_1; -.
DR   InParanoid; Q6CLP9; -.
DR   OMA; YMEQMVL; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblFungi.
DR   GO; GO:0006298; P:mismatch repair; IEA:EnsemblFungi.
DR   GO; GO:0070682; P:proteasome regulatory particle assembly; IEA:EnsemblFungi.
DR   InterPro; IPR040752; HSM3_C.
DR   InterPro; IPR041335; HSM3_N.
DR   Pfam; PF18794; HSM3_C; 1.
DR   Pfam; PF18795; HSM3_N; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..469
FT                   /note="DNA mismatch repair protein HSM3"
FT                   /id="PRO_0000301759"
SQ   SEQUENCE   469 AA;  53498 MW;  D690BE902D762D4D CRC64;
     MTDVTKDIDN LADALLTMEI SPEINDLMEK LALNLTSSNN LPVDVKHLLT SIKTYLTQSS
     SEMLDYNLLL EVLDAVVGLC PFEDVLKVFS VDDLITALKS GDKALTETVC QVIAAASPRD
     IFAGTPLLDE MLKLYFCEST VVAIVNALEK TLGILVTNQL NRRRILENNL PVLISVKDCK
     NSTTFCRFLD LIKILSASVT FEEFRKDIFI IDNMVTNKMM ENDILVFIHI CQYYIELLTI
     SLTEDGKEWV IRYVKPSFEI FGEAFSRREE LFDVGHFAKS YLLTLFSKIS YLDDKSYIQL
     LEAQFFPLYP DKQYLDEFLT VLDPSYIAKV HLDLLKEKAL RAGNVHMFVN LIKDEDCFVQ
     LKDEINSKTL NDMPYIEKML LLDGLTLTSY GIQHLTRNMP SVMNSIIDSG NQVTEKLSFD
     LRLRVFENLL EANPQELSVW LIPLQSEYAN ILNGRRGRFS SGQLADDYL