ID   HSM3_PICST              Reviewed;         497 AA.
AC   A3LY92;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JUL-2007, sequence version 2.
DT   25-MAY-2022, entry version 52.
DE   RecName: Full=DNA mismatch repair protein HSM3;
GN   Name=HSM3; ORFNames=PICST_62139;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Involved in DNA mismatch repair in slow-growing cells. Acts
CC       as a chaperone during the assembly of the 26S proteasome, specifically
CC       of the base subcomplex of the 19S regulatory complex (RC) (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the proteasome subunit S5B/HSM3 family.
CC       {ECO:0000305}.
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DR   EMBL; CP000500; ABN67941.2; -; Genomic_DNA.
DR   RefSeq; XP_001385970.2; XM_001385933.1.
DR   AlphaFoldDB; A3LY92; -.
DR   SMR; A3LY92; -.
DR   STRING; 4924.XP_001385970.2; -.
DR   EnsemblFungi; ABN67941; ABN67941; PICST_62139.
DR   GeneID; 4840403; -.
DR   KEGG; pic:PICST_62139; -.
DR   eggNOG; ENOG502QWEK; Eukaryota.
DR   HOGENOM; CLU_577450_0_0_1; -.
DR   InParanoid; A3LY92; -.
DR   OMA; YMEQMVL; -.
DR   OrthoDB; 1252574at2759; -.
DR   Proteomes; UP000002258; Chromosome 6.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   InterPro; IPR040752; HSM3_C.
DR   InterPro; IPR041335; HSM3_N.
DR   Pfam; PF18794; HSM3_C; 1.
DR   Pfam; PF18795; HSM3_N; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; DNA damage; DNA repair; Reference proteome.
FT   CHAIN           1..497
FT                   /note="DNA mismatch repair protein HSM3"
FT                   /id="PRO_0000301760"
SQ   SEQUENCE   497 AA;  56712 MW;  6105101392D3A706 CRC64;
     MPAPATTTSV DEQTLSVIDH LTKSYDNKSE IDSTLIDDYI TVLGSIDLLG AIADFIPIIN
     HILTDNLYHQ IDPNRLLIEL LQKIVSRLSF GQIVSVYSPE FIVSSLASSD NVPITKLCLS
     IIIQKLHEPE TVSFIAENCI SFILLKNYLS DAKLDLGIVN QIELYVNSLI LNDVTNLLEE
     ILTDTKFVIL YNSIRNSENT ILLARLLDFI LILLTYKVDL PLDPRLYTFS NVEIVTFKDD
     PLFLILLVQF YVKLVQFSVL EEVSPVIGNF VNLYKDPTTD DFVKVEVIDI LVKLSYATNS
     LLIEYGLELA LNSELFKSHN LIKVYEYNEP DIKLLSNVNP DLIVHSSNVI YEDVLSNLSL
     LNNKQYFPIL LNFIGSTDVF PRLEQDYFTT KLKHLPADKL YVILLEFSKF SHSRKFLLSN
     ATLTNDYLLD NDNLTFVNNE LWHTKLQVLE NLVNATDSDS PELAHWKPYL QDSFNLMRHG
     KKIRDVVPQV SILDETL