HSP11_CAEEL
ID HSP11_CAEEL Reviewed; 145 AA.
AC P34696;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Heat shock protein Hsp-16.1/Hsp-16.11;
GN Name=hsp-16.1; Synonyms=hsp16-1b; ORFNames=T27E4.8;
GN and
GN Name=hsp-16.11; Synonyms=hsp16-1a; ORFNames=T27E4.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=4033652; DOI=10.1128/mcb.5.6.1268-1278.1985;
RA Russnak R.H., Candido E.P.M.;
RT "Locus encoding a family of small heat shock genes in Caenorhabditis
RT elegans: two genes duplicated to form a 3.8-kilobase inverted repeat.";
RL Mol. Cell. Biol. 5:1268-1278(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HSP-16.1 AND HSP-16.11).
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 41-63.
RX PubMed=3588308; DOI=10.1093/nar/15.9.3723;
RA Kay R.J., Russnak R.H., Jones D., Mathias C., Candido E.P.M.;
RT "Expression of intron-containing C. elegans heat shock genes in mouse cells
RT demonstrates divergence of 3' splice site recognition sequences between
RT nematodes and vertebrates, and an inhibitory effect of heat shock on the
RT mammalian splicing apparatus.";
RL Nucleic Acids Res. 15:3723-3741(1987).
RN [4]
RP INDUCTION BY HEAT STRESS.
RX PubMed=26212459; DOI=10.1016/j.molcel.2015.06.027;
RA Labbadia J., Morimoto R.I.;
RT "Repression of the heat shock response is a programmed event at the onset
RT of reproduction.";
RL Mol. Cell 59:639-650(2015).
CC -!- INDUCTION: By heat stress. {ECO:0000269|PubMed:26212459}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; K03273; AAA28068.1; -; Genomic_DNA.
DR EMBL; FO080670; CCD65662.1; -; Genomic_DNA.
DR EMBL; FO080670; CCD65668.1; -; Genomic_DNA.
DR PIR; B24289; B24289.
DR RefSeq; NP_505354.1; NM_072953.3.
DR RefSeq; NP_505357.1; NM_072956.3.
DR AlphaFoldDB; P34696; -.
DR SMR; P34696; -.
DR BioGRID; 44324; 3.
DR BioGRID; 44327; 3.
DR IntAct; P34696; 1.
DR STRING; 6239.T27E4.2; -.
DR EPD; P34696; -.
DR PaxDb; P34696; -.
DR PeptideAtlas; P34696; -.
DR EnsemblMetazoa; T27E4.2.1; T27E4.2.1; WBGene00002017.
DR EnsemblMetazoa; T27E4.8.1; T27E4.8.1; WBGene00002015.
DR GeneID; 179286; -.
DR GeneID; 179289; -.
DR KEGG; cel:CELE_T27E4.2; -.
DR KEGG; cel:CELE_T27E4.8; -.
DR UCSC; T27E4.8; c. elegans.
DR CTD; 179286; -.
DR CTD; 179289; -.
DR WormBase; T27E4.2; CE14249; WBGene00002017; hsp-16.11.
DR WormBase; T27E4.8; CE14249; WBGene00002015; hsp-16.1.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00970000195989; -.
DR HOGENOM; CLU_095001_7_0_1; -.
DR InParanoid; P34696; -.
DR OMA; MINNESK; -.
DR OrthoDB; 1187096at2759; -.
DR PhylomeDB; P34696; -.
DR Reactome; R-CEL-3371571; HSF1-dependent transactivation.
DR PRO; PR:P34696; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00002015; Expressed in embryo and 2 other tissues.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0050829; P:defense response to Gram-negative bacterium; IGI:UniProtKB.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IBA:GO_Central.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640; PTHR45640; 1.
DR Pfam; PF00011; HSP20; 1.
DR PIRSF; PIRSF036514; Sm_HSP_B1; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Stress response.
FT CHAIN 1..145
FT /note="Heat shock protein Hsp-16.1/Hsp-16.11"
FT /id="PRO_0000125958"
FT DOMAIN 32..137
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
SQ SEQUENCE 145 AA; 16253 MW; 06C36A1F06D15A11 CRC64;
MSLYHYFRPA QRSVFGDLMR DMAQMERQFT PVCRGSPSES SEIVNNDQKF AINLNVSQFK
PEDLKINLDG HTLSIQGEQE LKTEHGYSKK SFSRVILLPE DVDVGAVASN LSEDGKLSIE
APKKEAIQGR SIPIQQAPVE QKTSE
