HSP12_CAEEL
ID HSP12_CAEEL Reviewed; 145 AA.
AC P06582;
DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1988, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Heat shock protein hsp-16.2 {ECO:0000305};
GN Name=hsp-16.2 {ECO:0000312|WormBase:Y46H3A.3a};
GN Synonyms=hsp-16 {ECO:0000312|WormBase:Y46H3A.3a},
GN hsp16-2 {ECO:0000312|WormBase:Y46H3A.3a};
GN ORFNames=Y46H3A.3 {ECO:0000312|WormBase:Y46H3A.3a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3017958; DOI=10.1016/s0021-9258(18)67194-7;
RA Jones D., Russnak R.H., Kay R.J., Candido E.P.M.;
RT "Structure, expression, and evolution of a heat shock gene locus in
RT Caenorhabditis elegans that is flanked by repetitive elements.";
RL J. Biol. Chem. 261:12006-12015(1986).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP INDUCTION.
RX PubMed=29500338; DOI=10.1038/s41467-018-02934-5;
RA De Magalhaes Filho C.D., Henriquez B., Seah N.E., Evans R.M.,
RA Lapierre L.R., Dillin A.;
RT "Visible light reduces C. elegans longevity.";
RL Nat. Commun. 9:927-927(2018).
CC -!- INDUCTION: Induced by white light exposure.
CC {ECO:0000269|PubMed:29500338}.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; M14334; AAA28071.1; -; Genomic_DNA.
DR EMBL; BX284605; CCD70651.1; -; Genomic_DNA.
DR PIR; B25199; B25199.
DR RefSeq; NP_503507.1; NM_071106.7.
DR AlphaFoldDB; P06582; -.
DR SMR; P06582; -.
DR BioGRID; 43724; 2.
DR IntAct; P06582; 1.
DR STRING; 6239.Y46H3A.3; -.
DR BindingDB; P06582; -.
DR ChEMBL; CHEMBL2146313; -.
DR EPD; P06582; -.
DR PaxDb; P06582; -.
DR PeptideAtlas; P06582; -.
DR EnsemblMetazoa; Y46H3A.3a.1; Y46H3A.3a.1; WBGene00002016.
DR GeneID; 178659; -.
DR KEGG; cel:CELE_Y46H3A.3; -.
DR UCSC; Y46H3A.3; c. elegans.
DR CTD; 178659; -.
DR WormBase; Y46H3A.3a; CE22002; WBGene00002016; hsp-16.2.
DR eggNOG; KOG3591; Eukaryota.
DR InParanoid; P06582; -.
DR OMA; NTEGHER; -.
DR OrthoDB; 1187096at2759; -.
DR PhylomeDB; P06582; -.
DR Reactome; R-CEL-3371571; HSF1-dependent transactivation.
DR PRO; PR:P06582; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00002016; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR ExpressionAtlas; P06582; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:0051082; F:unfolded protein binding; ISS:WormBase.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IEP:UniProtKB.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640; PTHR45640; 1.
DR Pfam; PF00011; HSP20; 1.
DR PIRSF; PIRSF036514; Sm_HSP_B1; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Stress response.
FT CHAIN 1..145
FT /note="Heat shock protein hsp-16.2"
FT /id="PRO_0000125959"
FT DOMAIN 32..137
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
SQ SEQUENCE 145 AA; 16242 MW; 8A73449F99161889 CRC64;
MSLYHYFRPA QRSVFGDLMR DMALMERQFA PVCRISPSES SEIVNNDQKF AINLNVSQFK
PEDLKINLDG RTLSIQGEQE LKTDHGYSKK SFSRVILLPE DVDVGAVASN LSEDGKLSIE
APKKEAVQGR SIPIQQAIVE EKSAE
