HSP17_CAEEL
ID HSP17_CAEEL Reviewed; 143 AA.
AC P02513; Q27922;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 13-AUG-1987, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Heat shock protein Hsp-16.48/Hsp-16.49;
GN Name=hsp-16.48; Synonyms=hsp16-48, hsp16-48a; ORFNames=T27E4.3;
GN and
GN Name=hsp-16.49; Synonyms=hsp16-48b, hsp16-49; ORFNames=T27E4.9;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] (HSP-16.48 AND HSP-16.49).
RX PubMed=4033652; DOI=10.1128/mcb.5.6.1268-1278.1985;
RA Russnak R.H., Candido E.P.M.;
RT "Locus encoding a family of small heat shock genes in Caenorhabditis
RT elegans: two genes duplicated to form a 3.8-kilobase inverted repeat.";
RL Mol. Cell. Biol. 5:1268-1278(1985).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (HSP-16.48 AND HSP-16.49).
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 9-143.
RX PubMed=6190129; DOI=10.1093/nar/11.10.3187;
RA Russnak R.H., Jones D., Candido E.P.M.;
RT "Cloning and analysis of cDNA sequences coding for two 16 kilodalton heat
RT shock proteins (hsps) in Caenorhabditis elegans: homology with the small
RT hsps of Drosophila.";
RL Nucleic Acids Res. 11:3187-3205(1983).
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR EMBL; K03273; AAA28067.1; -; Genomic_DNA.
DR EMBL; K03273; AAA28069.1; -; Genomic_DNA.
DR EMBL; FO080670; CCD65663.1; -; Genomic_DNA.
DR EMBL; FO080670; CCD65669.1; -; Genomic_DNA.
DR EMBL; X01576; CAA25731.1; -; mRNA.
DR PIR; A24289; HHKW48.
DR RefSeq; NP_505355.1; NM_072954.3.
DR RefSeq; NP_505356.1; NM_072955.3.
DR AlphaFoldDB; P02513; -.
DR SMR; P02513; -.
DR BioGRID; 44325; 1.
DR BioGRID; 44326; 7.
DR STRING; 6239.T27E4.3; -.
DR EPD; P02513; -.
DR PaxDb; P02513; -.
DR PeptideAtlas; P02513; -.
DR EnsemblMetazoa; T27E4.3.1; T27E4.3.1; WBGene00002019.
DR EnsemblMetazoa; T27E4.9.1; T27E4.9.1; WBGene00002020.
DR GeneID; 179287; -.
DR GeneID; 179288; -.
DR KEGG; cel:CELE_T27E4.3; -.
DR KEGG; cel:CELE_T27E4.9; -.
DR UCSC; T27E4.3; c. elegans.
DR CTD; 179287; -.
DR CTD; 179288; -.
DR WormBase; T27E4.3; CE14251; WBGene00002019; hsp-16.48.
DR WormBase; T27E4.9; CE14251; WBGene00002020; hsp-16.49.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00970000196196; -.
DR HOGENOM; CLU_095001_4_1_1; -.
DR InParanoid; P02513; -.
DR OMA; DRIMEEY; -.
DR OrthoDB; 1187096at2759; -.
DR PhylomeDB; P02513; -.
DR Reactome; R-CEL-3371571; HSF1-dependent transactivation.
DR PRO; PR:P02513; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00002019; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0009408; P:response to heat; IBA:GO_Central.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640; PTHR45640; 1.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Stress response.
FT CHAIN 1..143
FT /note="Heat shock protein Hsp-16.48/Hsp-16.49"
FT /id="PRO_0000125961"
FT DOMAIN 35..140
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT CONFLICT 46
FT /note="E -> EQ (in Ref. 1; AAA28067)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 143 AA; 16299 MW; 0D5596DFEE5B3318 CRC64;
MLMLRSPFSD SNVLDHFLDE ITGSVQFPYW RNADHNSFNF SDNIGEIVND ESKFSVQLDV
SHFKPEDLKI ELDGRELKIE GIQEKKSEHG YSKRSFSKMI LLPEDVDLTS VKSAISNEGK
LQIEAPKKTN SSRSIPINFV AKH
