HSP1_ALLMI
ID HSP1_ALLMI Reviewed; 57 AA.
AC Q7LZB6;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=Sperm protamine P1-type;
DE AltName: Full=Protamine II;
OS Alligator mississippiensis (American alligator).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Crocodylia; Alligatoridae; Alligatorinae;
OC Alligator.
OX NCBI_TaxID=8496;
RN [1]
RP PROTEIN SEQUENCE OF 2-57.
RC TISSUE=Sperm;
RX PubMed=8798564; DOI=10.1074/jbc.271.38.23547;
RA Hunt J.G., Kasinsky H.E., Elsey R.M., Wright C.L., Rice P., Bell J.E.,
RA Sharp D.J., Kiss A.J., Hunt D.F., Arnott D.P., Russ M.M., Shabanowitz J.,
RA Ausio J.;
RT "Protamines of reptiles.";
RL J. Biol. Chem. 271:23547-23557(1996).
CC -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC during the haploid phase of spermatogenesis. They compact sperm DNA
CC into a highly condensed, stable and inactive complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
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DR PIR; C58213; C58213.
DR AlphaFoldDB; Q7LZB6; -.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR InterPro; IPR000221; Protamine_P1.
DR PROSITE; PS00048; PROTAMINE_P1; 1.
PE 1: Evidence at protein level;
KW Chromosome; Developmental protein; Differentiation;
KW Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW Nucleus; Spermatogenesis.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8798564"
FT CHAIN 2..57
FT /note="Sperm protamine P1-type"
FT /id="PRO_0000191591"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 57 AA; 7669 MW; 2894208FCFAFB9F7 CRC64;
MARYRHNRSR SRSRHRRRRR GHRGGRYRRR RRRGRYGHRR HHRGHSRRRR KRRRSRH