HSP1_CAPHI
ID HSP1_CAPHI Reviewed; 51 AA.
AC P67833; P04102;
DT 01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 40.
DE RecName: Full=Sperm protamine P1;
DE AltName: Full=Cysteine-rich protamine;
GN Name=PRM1; Synonyms=PRM-1;
OS Capra hircus (Goat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Capra.
OX NCBI_TaxID=9925;
RN [1]
RP PROTEIN SEQUENCE OF 2-51.
RX PubMed=3060372; DOI=10.1016/0014-5793(88)80996-7;
RA Ammer H., Henschen A.;
RT "Primary structure of rabbit sperm protamine, the first protamine of its
RT type with an aberrant N-terminal.";
RL FEBS Lett. 242:111-116(1988).
CC -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC during the haploid phase of spermatogenesis. They compact sperm DNA
CC into a highly condensed, stable and inactive complex.
CC -!- SUBUNIT: Cross-linked by interchain disulfide bonds around the DNA-
CC helix. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
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DR AlphaFoldDB; P67833; -.
DR PRIDE; P67833; -.
DR Ensembl; ENSCHIT00010042443; ENSCHIP00010030111; ENSCHIG00010022404.
DR Proteomes; UP000291000; Unplaced.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR InterPro; IPR000221; Protamine_P1.
DR Pfam; PF00260; Protamine_P1; 1.
DR PROSITE; PS00048; PROTAMINE_P1; 1.
PE 1: Evidence at protein level;
KW Chromosome; Developmental protein; Differentiation;
KW Direct protein sequencing; Disulfide bond; DNA condensation; DNA-binding;
KW Nucleosome core; Nucleus; Reference proteome; Spermatogenesis.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:3060372"
FT CHAIN 2..51
FT /note="Sperm protamine P1"
FT /id="PRO_0000191453"
FT DISULFID 6
FT /note="Interchain (with C-23)"
FT /evidence="ECO:0000250|UniProtKB:P02318"
FT DISULFID 7..15
FT /evidence="ECO:0000250|UniProtKB:P02318"
FT DISULFID 23
FT /note="Interchain (with C-6)"
FT /evidence="ECO:0000250|UniProtKB:P02318"
FT DISULFID 39
FT /note="Interchain (with C-39)"
FT /evidence="ECO:0000250|UniProtKB:P02318"
FT DISULFID 40..48
FT /evidence="ECO:0000250|UniProtKB:P02318"
SQ SEQUENCE 51 AA; 6843 MW; 6B2A01843B8072DA CRC64;
MARYRCCLTH SRSRCRRRRR RRCRRRRRRF GRRRRRRVCC RRYTVVRCTR Q