ID   HSP1_CAVPO              Reviewed;          48 AA.
AC   P35304;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Sperm protamine P1;
DE   AltName: Full=Cysteine-rich protamine;
GN   Name=PRM1; Synonyms=PRM-1;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=JM109;
RA   Queralt R., Adroer R., Oliva R.;
RL   Submitted (DEC-1991) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBUNIT: Cross-linked by interchain disulfide bonds around the DNA-
CC       helix.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
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DR   EMBL; M83896; AAA58349.1; -; Genomic_DNA.
DR   EMBL; Z11544; CAA77643.1; -; mRNA.
DR   EMBL; Z11545; CAA77644.1; -; Genomic_DNA.
DR   PIR; S29973; S29973.
DR   RefSeq; NP_001166477.1; NM_001173006.1.
DR   AlphaFoldDB; P35304; -.
DR   GeneID; 100135606; -.
DR   KEGG; cpoc:100135606; -.
DR   CTD; 5619; -.
DR   HOGENOM; CLU_214580_2_0_1; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR   InterPro; IPR000221; Protamine_P1.
DR   Pfam; PF00260; Protamine_P1; 1.
DR   PROSITE; PS00048; PROTAMINE_P1; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Developmental protein; Differentiation; Disulfide bond;
KW   DNA condensation; DNA-binding; Nucleosome core; Nucleus;
KW   Reference proteome; Spermatogenesis.
FT   CHAIN           1..48
FT                   /note="Sperm protamine P1"
FT                   /id="PRO_0000191454"
SQ   SEQUENCE   48 AA;  6684 MW;  6481B24E37DE7017 CRC64;
     MARYRCCRSP SRSRCRRRRR RFYRRRRRCH RRRRRCCRRR YTRRCKRY