HSP1_CHICK
ID HSP1_CHICK Reviewed; 62 AA.
AC P15340; P02320;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 86.
DE RecName: Full=Sperm histone;
DE AltName: Full=Galline;
DE AltName: Full=Protamine;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2745455; DOI=10.1016/s0021-9258(18)63883-9;
RA Oliva R., Dixon G.H.;
RT "Chicken protamine genes are intronless. The complete genomic sequence and
RT organization of the two loci.";
RL J. Biol. Chem. 264:12472-12481(1989).
RN [2]
RP PROTEIN SEQUENCE OF 2-62.
RC TISSUE=Sperm;
RX PubMed=992941;
RA Nakano M., Tobita T., Ando T.;
RT "Studies on a protamine (galline) from fowl sperm. 3. The total amino acid
RT sequence of intact galline molecule.";
RL Int. J. Pept. Protein Res. 8:565-578(1976).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 49-62.
RX PubMed=2892748; DOI=10.1016/0012-1606(88)90216-3;
RA Oliva R., Mezquita J., Mezquita C., Dixon G.H.;
RT "Haploid expression of the rooster protamine mRNA in the postmeiotic stages
RT of spermatogenesis.";
RL Dev. Biol. 125:332-340(1988).
CC -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC during the haploid phase of spermatogenesis. They compact sperm DNA
CC into a highly condensed, stable and inactive complex.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=Ref.2; Type=Miscellaneous discrepancy; Note=Very different from the sequence obtained by DNA sequencing.; Evidence={ECO:0000305};
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DR EMBL; L38713; AAA58721.1; -; Genomic_DNA.
DR EMBL; M28100; AAA78951.1; -; Genomic_DNA.
DR EMBL; M19078; AAA49049.1; ALT_SEQ; mRNA.
DR PIR; A02662; GACH.
DR PIR; A34326; A34326.
DR AlphaFoldDB; P15340; -.
DR iPTMnet; P15340; -.
DR Ensembl; ENSGALT00000057249; ENSGALP00000055563; ENSGALG00000049332.
DR Ensembl; ENSGALT00000069922; ENSGALP00000057334; ENSGALG00000054019.
DR GeneTree; ENSGT00860000136294; -.
DR OMA; MARYICC; -.
DR PRO; PR:P15340; -.
DR Proteomes; UP000000539; Chromosome 4.
DR Bgee; ENSGALG00000049332; Expressed in spermatid and 6 other tissues.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IDA:CAFA.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR DisProt; DP00057; -.
DR InterPro; IPR000221; Protamine_P1.
DR PROSITE; PS00048; PROTAMINE_P1; 1.
PE 1: Evidence at protein level;
KW Chromosome; Developmental protein; Differentiation;
KW Direct protein sequencing; DNA condensation; DNA-binding; Nucleosome core;
KW Nucleus; Phosphoprotein; Reference proteome; Spermatogenesis.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:992941"
FT CHAIN 2..62
FT /note="Sperm histone"
FT /id="PRO_0000191589"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 9
FT /note="Phosphothreonine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 62 AA; 8117 MW; 7F88D7BD3A3EE7A3 CRC64;
MARYRRSRTR SRSPRSRRRR RRSGRRRSPR RRRRYGSARR SRRSVGGRRR RYGSRRRRRR
RY
