ID   HSP1_EQUAS              Reviewed;          50 AA.
AC   Q66QC7;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Sperm protamine P1;
GN   Name=PRM1;
OS   Equus asinus (Donkey) (Equus africanus asinus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX   NCBI_TaxID=9793;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Zhao C.J., Wu C.H., Han G.C., Qin Y.H., Wu K.L., Du Y.C.;
RT   "Species identification among horse (Equus caballus) and donkey (Equus
RT   asinus) and their hybrids by PCR-RFLP.";
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Cross-linked by interchain disulfide bonds around the DNA-
CC       helix. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
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DR   EMBL; AY726547; AAU12842.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q66QC7; -.
DR   OMA; MARYICC; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR   InterPro; IPR000221; Protamine_P1.
DR   Pfam; PF00260; Protamine_P1; 1.
DR   PROSITE; PS00048; PROTAMINE_P1; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Developmental protein; Differentiation; Disulfide bond;
KW   DNA condensation; DNA-binding; Nucleosome core; Nucleus; Spermatogenesis.
FT   CHAIN           1..50
FT                   /note="Sperm protamine P1"
FT                   /id="PRO_0000191478"
FT   DISULFID        6
FT                   /note="Interchain (with C-23)"
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
FT   DISULFID        7..15
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
FT   DISULFID        23
FT                   /note="Interchain (with C-6)"
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
FT   DISULFID        37
FT                   /note="Interchain (with C-37)"
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
FT   DISULFID        38..46
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
SQ   SEQUENCE   50 AA;  6774 MW;  BF655ED87F50AE74 CRC64;
     MARYRCCRSQ SQSRCRRRRR RRCRRRRRRC VRRRRVCCRR YTVLRCRRRR