HSP1_HORSE
ID HSP1_HORSE Reviewed; 50 AA.
AC P15341;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Sperm protamine P1;
DE AltName: Full=Cysteine-rich protamine;
DE AltName: Full=Protamine ST1;
GN Name=PRM1; Synonyms=PRM-1;
OS Equus caballus (Horse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
OX NCBI_TaxID=9796;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Skow L.C., Massey V.K.;
RT "Sequence of a horse protamine-1 (PRM-1) gene and its flanking regions.";
RL Submitted (OCT-1993) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP PROTEIN SEQUENCE OF 2-50.
RX PubMed=3593735; DOI=10.1016/0167-4838(87)90323-2;
RA Belaiche D., Loir M., Kruggle W., Sautiere P.;
RT "Isolation and characterization of two protamines St1 and St2 from stallion
RT spermatozoa, and amino-acid sequence of the major protamine St1.";
RL Biochim. Biophys. Acta 913:145-149(1987).
RN [3]
RP PROTEIN SEQUENCE OF 2-49.
RX PubMed=3442606; DOI=10.1515/bchm3.1987.368.2.1619;
RA Ammer H., Henschen A.;
RT "The major protamine from stallion sperm. Isolation and amino-acid
RT sequence.";
RL Biol. Chem. Hoppe-Seyler 368:1619-1626(1987).
CC -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC during the haploid phase of spermatogenesis. They compact sperm DNA
CC into a highly condensed, stable and inactive complex.
CC -!- SUBUNIT: Cross-linked by interchain disulfide bonds around the DNA-
CC helix.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
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DR EMBL; L10654; AAA30957.1; -; Genomic_DNA.
DR PIR; S00228; S00228.
DR RefSeq; NP_001077065.1; NM_001083596.1.
DR AlphaFoldDB; P15341; -.
DR Ensembl; ENSECAT00000021217; ENSECAP00000017464; ENSECAG00000020028.
DR GeneID; 100036554; -.
DR KEGG; ecb:100036554; -.
DR CTD; 5619; -.
DR HOGENOM; CLU_214580_0_0_1; -.
DR Proteomes; UP000002281; Chromosome 13.
DR Bgee; ENSECAG00000020028; Expressed in testis and 2 other tissues.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR InterPro; IPR000221; Protamine_P1.
DR Pfam; PF00260; Protamine_P1; 1.
DR PROSITE; PS00048; PROTAMINE_P1; 1.
PE 1: Evidence at protein level;
KW Chromosome; Developmental protein; Differentiation;
KW Direct protein sequencing; Disulfide bond; DNA condensation; DNA-binding;
KW Nucleosome core; Nucleus; Reference proteome; Spermatogenesis.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:3442606,
FT ECO:0000269|PubMed:3593735"
FT CHAIN 2..50
FT /note="Sperm protamine P1"
FT /id="PRO_0000191481"
FT DISULFID 6
FT /note="Interchain (with C-23)"
FT /evidence="ECO:0000250|UniProtKB:P02318"
FT DISULFID 7..15
FT /evidence="ECO:0000250|UniProtKB:P02318"
FT DISULFID 23
FT /note="Interchain (with C-6)"
FT /evidence="ECO:0000250|UniProtKB:P02318"
FT DISULFID 37
FT /note="Interchain (with C-37)"
FT /evidence="ECO:0000250|UniProtKB:P02318"
FT DISULFID 38..46
FT /evidence="ECO:0000250|UniProtKB:P02318"
SQ SEQUENCE 50 AA; 6730 MW; BF67334862E7AE74 CRC64;
MARYRCCRSQ SQSRCRRRRR RRCRRRRRRS VRQRRVCCRR YTVLRCRRRR
