HSP1_PLEAU
ID HSP1_PLEAU Reviewed; 50 AA.
AC Q8WNZ1;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 44.
DE RecName: Full=Sperm protamine P1;
GN Name=PRM1;
OS Plecotus auritus (Long-eared bat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Chiroptera; Microchiroptera; Vespertilionidae;
OC Plecotus.
OX NCBI_TaxID=61862;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11884158; DOI=10.1006/mpev.2001.1051;
RA Van Den Bussche R.A., Hoofer S.R., Hansen E.W.;
RT "Characterization and phylogenetic utility of the mammalian protamine P1
RT gene.";
RL Mol. Phylogenet. Evol. 22:333-341(2002).
CC -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC during the haploid phase of spermatogenesis. They compact sperm DNA
CC into a highly condensed, stable and inactive complex (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Testis.
CC -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
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DR EMBL; AF435939; AAL35573.1; -; Genomic_DNA.
DR AlphaFoldDB; Q8WNZ1; -.
DR GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR InterPro; IPR000221; Protamine_P1.
DR Pfam; PF00260; Protamine_P1; 1.
DR PROSITE; PS00048; PROTAMINE_P1; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Developmental protein; Differentiation; DNA condensation;
KW DNA-binding; Nucleosome core; Nucleus; Spermatogenesis.
FT CHAIN 1..50
FT /note="Sperm protamine P1"
FT /id="PRO_0000191538"
SQ SEQUENCE 50 AA; 6799 MW; D42AB9CB1C81100E CRC64;
MARYRCCRSQ SRSRCRRRRR RCYRRRRRCC RRRRRRVCCR RYTVVRCRRR