ID   HSP1_PONPY              Reviewed;          51 AA.
AC   P35310;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Sperm protamine P1;
DE   AltName: Full=Cysteine-rich protamine;
GN   Name=PRM1;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8308910; DOI=10.1007/bf00178872;
RA   Retief J.D., Winkfein R.J., Dixon G.H., Adroer R., Queralt R.,
RA   Ballabriga J., Oliva R.;
RT   "Evolution of protamine P1 genes in primates.";
RL   J. Mol. Evol. 37:426-434(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10659848; DOI=10.1038/35002070;
RA   Wyckoff G.J., Wang W., Wu C.-I.;
RT   "Rapid evolution of male reproductive genes in the descent of man.";
RL   Nature 403:304-309(2000).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBUNIT: Cross-linked by interchain disulfide bonds around the DNA-
CC       helix. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
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DR   EMBL; L14589; AAA36946.1; -; Genomic_DNA.
DR   EMBL; AF215710; AAF34623.1; -; Genomic_DNA.
DR   AlphaFoldDB; P35310; -.
DR   PRIDE; P35310; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR   InterPro; IPR000221; Protamine_P1.
DR   Pfam; PF00260; Protamine_P1; 1.
DR   PROSITE; PS00048; PROTAMINE_P1; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Developmental protein; Differentiation; Disulfide bond;
KW   DNA condensation; DNA-binding; Nucleosome core; Nucleus; Spermatogenesis.
FT   CHAIN           1..51
FT                   /note="Sperm protamine P1"
FT                   /id="PRO_0000191540"
SQ   SEQUENCE   51 AA;  6791 MW;  D99322A9A7478E78 CRC64;
     MARYRCCRSQ SQSRCCRRRQ RCHRRRRRCC QTRRRAMRCC RRRYRLRCRR H