ID   HSP1_SAGIM              Reviewed;          50 AA.
AC   P24714;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Sperm protamine P1;
DE   AltName: Full=Cysteine-rich protamine;
GN   Name=PRM1;
OS   Saguinus imperator (Emperor tamarin).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Callitrichinae; Saguinus.
OX   NCBI_TaxID=9491;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=1840669; DOI=10.1093/nar/19.20.5786;
RA   Queralt R., Oliva R.;
RT   "Protamine 1 gene sequence from the primate Saguinus imperator isolated
RT   with PCR using consensus oligonucleotides.";
RL   Nucleic Acids Res. 19:5786-5786(1991).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBUNIT: Cross-linked by interchain disulfide bonds around the DNA-
CC       helix. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X61678; CAA43853.1; -; Genomic_DNA.
DR   PIR; S22582; S22582.
DR   AlphaFoldDB; P24714; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR   InterPro; IPR000221; Protamine_P1.
DR   Pfam; PF00260; Protamine_P1; 1.
DR   PROSITE; PS00048; PROTAMINE_P1; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Developmental protein; Differentiation; Disulfide bond;
KW   DNA condensation; DNA-binding; Nucleosome core; Nucleus; Spermatogenesis.
FT   CHAIN           1..50
FT                   /note="Sperm protamine P1"
FT                   /id="PRO_0000191552"
SQ   SEQUENCE   50 AA;  6676 MW;  83F099B5578207F6 CRC64;
     MARYRCCRSQ SRSRCYRQRR RGRRRRRRTC RRRRASRCCR RRYKLTCRRY