ID   HSP1_SHEEP              Reviewed;          51 AA.
AC   P68038; P04102;
DT   01-NOV-1986, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Sperm protamine P1;
DE   AltName: Full=Cysteine-rich protamine;
GN   Name=PRM1; Synonyms=PRM-1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-51.
RX   PubMed=6479168; DOI=10.1111/j.1432-1033.1984.tb08439.x;
RA   Sautiere P., Belaiche D., Martinage A., Loir M.;
RT   "Primary structure of the ram (Ovis aries) protamine.";
RL   Eur. J. Biochem. 144:121-125(1984).
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex.
CC   -!- SUBUNIT: Cross-linked by interchain disulfide bonds around the DNA-
CC       helix. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Chromosome.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
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DR   PIR; A02658; HSSH.
DR   RefSeq; NP_001156522.1; NM_001163050.1.
DR   AlphaFoldDB; P68038; -.
DR   Ensembl; ENSOART00020026337; ENSOARP00020021853; ENSOARG00020017108.
DR   GeneID; 100302352; -.
DR   KEGG; oas:100302352; -.
DR   CTD; 5619; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR   InterPro; IPR000221; Protamine_P1.
DR   Pfam; PF00260; Protamine_P1; 1.
DR   PROSITE; PS00048; PROTAMINE_P1; 1.
PE   1: Evidence at protein level;
KW   Chromosome; Developmental protein; Differentiation;
KW   Direct protein sequencing; Disulfide bond; DNA condensation; DNA-binding;
KW   Nucleosome core; Nucleus; Reference proteome; Spermatogenesis.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:6479168"
FT   CHAIN           2..51
FT                   /note="Sperm protamine P1"
FT                   /id="PRO_0000191557"
FT   DISULFID        6
FT                   /note="Interchain (with C-23)"
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
FT   DISULFID        7..15
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
FT   DISULFID        23
FT                   /note="Interchain (with C-6)"
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
FT   DISULFID        39
FT                   /note="Interchain (with C-39)"
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
FT   DISULFID        40..48
FT                   /evidence="ECO:0000250|UniProtKB:P02318"
SQ   SEQUENCE   51 AA;  6843 MW;  6B2A01843B8072DA CRC64;
     MARYRCCLTH SRSRCRRRRR RRCRRRRRRF GRRRRRRVCC RRYTVVRCTR Q