ID   HSP1_TRAJO              Reviewed;          51 AA.
AC   Q8MJS8; Q8MJS9;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 43.
DE   RecName: Full=Sperm protamine P1;
GN   Name=PRM1;
OS   Trachypithecus johnii (Nilgiri langur) (Semnopithecus johnii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Colobinae; Trachypithecus.
OX   NCBI_TaxID=66063;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate NL1, and Isolate NL2;
RA   Karanth P.K., Singh L., Stewart C.-B.;
RT   "Molecular systematics of the langurs.";
RL   Submitted (AUG-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Protamines substitute for histones in the chromatin of sperm
CC       during the haploid phase of spermatogenesis. They compact sperm DNA
CC       into a highly condensed, stable and inactive complex (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Testis.
CC   -!- SIMILARITY: Belongs to the protamine P1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF294853; AAM68936.1; -; Genomic_DNA.
DR   EMBL; AF294854; AAM68937.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8MJS8; -.
DR   PRIDE; Q8MJS8; -.
DR   GO; GO:0000786; C:nucleosome; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR   GO; GO:0035092; P:sperm DNA condensation; IEA:InterPro.
DR   InterPro; IPR000221; Protamine_P1.
DR   Pfam; PF00260; Protamine_P1; 1.
DR   PROSITE; PS00048; PROTAMINE_P1; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Developmental protein; Differentiation; DNA condensation;
KW   DNA-binding; Nucleosome core; Nucleus; Spermatogenesis.
FT   CHAIN           1..51
FT                   /note="Sperm protamine P1"
FT                   /id="PRO_0000191582"
FT   VARIANT         28
FT                   /note="Q -> R (in strain: Isolate NL1)"
SQ   SEQUENCE   51 AA;  6810 MW;  46839B87DF2FE3E5 CRC64;
     MARYRRCRSQ SRSRCCRPRR RCRRRRRQSC RARRRATRCC RRRYRLRCRR Y