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HSP23_DROME
ID   HSP23_DROME             Reviewed;         186 AA.
AC   P02516; Q9VSX5;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 2.
DT   03-AUG-2022, entry version 172.
DE   RecName: Full=Heat shock protein 23;
GN   Name=Hsp23; ORFNames=CG4463;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6302284; DOI=10.1016/s0022-2836(83)80241-1;
RA   Southgate R., Ayme A., Voellmy R.;
RT   "Nucleotide sequence analysis of the Drosophila small heat shock gene
RT   cluster at locus 67B.";
RL   J. Mol. Biol. 165:35-57(1983).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6285380; DOI=10.1073/pnas.79.7.2360;
RA   Ingolia T.D., Craig E.A.;
RT   "Four small Drosophila heat shock proteins are related to each other and to
RT   mammalian alpha-crystallin.";
RL   Proc. Natl. Acad. Sci. U.S.A. 79:2360-2364(1982).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC   -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00285}.
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DR   EMBL; J01100; AAA28637.1; -; Genomic_DNA.
DR   EMBL; V00210; CAA23494.1; -; Genomic_DNA.
DR   EMBL; X03889; CAA27525.1; -; Genomic_DNA.
DR   EMBL; AE014296; AAF50286.1; -; Genomic_DNA.
DR   EMBL; AY061081; AAL28629.1; -; mRNA.
DR   PIR; A02919; HHFF23.
DR   PIR; B20647; B20647.
DR   RefSeq; NP_001246694.1; NM_001259765.2.
DR   RefSeq; NP_523999.1; NM_079275.4.
DR   AlphaFoldDB; P02516; -.
DR   SMR; P02516; -.
DR   BioGRID; 64472; 65.
DR   DIP; DIP-18765N; -.
DR   IntAct; P02516; 7.
DR   STRING; 7227.FBpp0301282; -.
DR   PaxDb; P02516; -.
DR   PRIDE; P02516; -.
DR   DNASU; 39077; -.
DR   EnsemblMetazoa; FBtr0076453; FBpp0076181; FBgn0001224.
DR   EnsemblMetazoa; FBtr0309504; FBpp0301282; FBgn0001224.
DR   GeneID; 39077; -.
DR   KEGG; dme:Dmel_CG4463; -.
DR   CTD; 39077; -.
DR   FlyBase; FBgn0001224; Hsp23.
DR   VEuPathDB; VectorBase:FBgn0001224; -.
DR   eggNOG; KOG3591; Eukaryota.
DR   GeneTree; ENSGT00940000166889; -.
DR   HOGENOM; CLU_095001_3_0_1; -.
DR   InParanoid; P02516; -.
DR   OMA; QDNGNDK; -.
DR   OrthoDB; 1187096at2759; -.
DR   PhylomeDB; P02516; -.
DR   Reactome; R-DME-3371571; HSF1-dependent transactivation.
DR   SignaLink; P02516; -.
DR   BioGRID-ORCS; 39077; 0 hits in 3 CRISPR screens.
DR   ChiTaRS; Hsp23; fly.
DR   GenomeRNAi; 39077; -.
DR   PRO; PR:P02516; -.
DR   Proteomes; UP000000803; Chromosome 3L.
DR   Bgee; FBgn0001224; Expressed in embryonic/larval hemocyte (Drosophila) and 41 other tissues.
DR   ExpressionAtlas; P02516; baseline and differential.
DR   Genevisible; P02516; DM.
DR   GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR   GO; GO:0051082; F:unfolded protein binding; IDA:FlyBase.
DR   GO; GO:0061077; P:chaperone-mediated protein folding; IDA:FlyBase.
DR   GO; GO:0009631; P:cold acclimation; IEP:FlyBase.
DR   GO; GO:0042026; P:protein refolding; IDA:FlyBase.
DR   GO; GO:0009408; P:response to heat; IDA:FlyBase.
DR   GO; GO:0001666; P:response to hypoxia; IMP:FlyBase.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR   InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   PANTHER; PTHR45640; PTHR45640; 1.
DR   Pfam; PF00011; HSP20; 1.
DR   PRINTS; PR00299; ACRYSTALLIN.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS01031; SHSP; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Stress response.
FT   CHAIN           1..186
FT                   /note="Heat shock protein 23"
FT                   /id="PRO_0000125964"
FT   DOMAIN          53..161
FT                   /note="sHSP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT   REGION          163..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        31..33
FT                   /note="QRN -> RRI (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        81
FT                   /note="K -> E (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        88
FT                   /note="K -> G (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        95
FT                   /note="L -> V (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        173
FT                   /note="N -> S (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        182
FT                   /note="N -> G (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   186 AA;  20629 MW;  3C6EDCDA1719B5A0 CRC64;
     MANIPLLLSL ADDLGRMSMV PFYEPYYCQR QRNPYLALVG PMEQQLRQLE KQVGASSGSS
     GAVSKIGKDG FQVCMDVSHF KPSELVVKVQ DNSVLVEGNH EEREDDHGFI TRHFVRRYAL
     PPGYEADKVA STLSSDGVLT IKVPKPPAIE DKGNERIVQI QQVGPAHLNV KENPKEAVEQ
     DNGNDK
 
 
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