HSP6C_DROME
ID HSP6C_DROME Reviewed; 199 AA.
AC P22979; Q4V3R7; Q9VSW9;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 15-JUN-2010, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Heat shock protein 67B3;
DE AltName: Full=Heat shock 18 kDa protein;
GN Name=Hsp67Bc; ORFNames=CG4190;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3123699; DOI=10.1016/0022-2836(87)90309-3;
RA Pauli D., Tonka C.H.;
RT "A Drosophila heat shock gene from locus 67B is expressed during
RT embryogenesis and pupation.";
RL J. Mol. Biol. 198:235-240(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J., Chavez C., Frise E., George R., Pacleb J.,
RA Park S., Wan K., Yu C., Celniker S.;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- INTERACTION:
CC P22979; Q94524: Dlc90F; NbExp=6; IntAct=EBI-165408, EBI-158251;
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis and pupation.
CC -!- SIMILARITY: Belongs to the small heat shock protein (HSP20) family.
CC {ECO:0000255|PROSITE-ProRule:PRU00285}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA29788.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; X06542; CAA29788.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AE014296; AAF50292.1; -; Genomic_DNA.
DR EMBL; BT023289; AAY55705.1; -; mRNA.
DR PIR; S00900; S00900.
DR RefSeq; NP_523994.1; NM_079270.3.
DR AlphaFoldDB; P22979; -.
DR SMR; P22979; -.
DR BioGRID; 64468; 5.
DR IntAct; P22979; 19.
DR STRING; 7227.FBpp0076225; -.
DR PaxDb; P22979; -.
DR PRIDE; P22979; -.
DR DNASU; 39071; -.
DR EnsemblMetazoa; FBtr0076497; FBpp0076225; FBgn0001229.
DR GeneID; 39071; -.
DR KEGG; dme:Dmel_CG4190; -.
DR CTD; 39071; -.
DR FlyBase; FBgn0001229; Hsp67Bc.
DR VEuPathDB; VectorBase:FBgn0001229; -.
DR eggNOG; KOG3591; Eukaryota.
DR GeneTree; ENSGT00940000166889; -.
DR HOGENOM; CLU_095001_1_1_1; -.
DR InParanoid; P22979; -.
DR OMA; RQHHDLD; -.
DR OrthoDB; 1187096at2759; -.
DR PhylomeDB; P22979; -.
DR Reactome; R-DME-3371571; HSF1-dependent transactivation.
DR BioGRID-ORCS; 39071; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Hsp67Bc; fly.
DR GenomeRNAi; 39071; -.
DR PRO; PR:P22979; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0001229; Expressed in saliva-secreting gland and 23 other tissues.
DR Genevisible; P22979; DM.
DR GO; GO:0051082; F:unfolded protein binding; ISM:FlyBase.
DR GO; GO:0061077; P:chaperone-mediated protein folding; ISM:FlyBase.
DR GO; GO:1903061; P:positive regulation of protein lipidation; IMP:FlyBase.
DR GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR GO; GO:0010506; P:regulation of autophagy; IMP:FlyBase.
DR GO; GO:0010998; P:regulation of translational initiation by eIF2 alpha phosphorylation; IMP:FlyBase.
DR GO; GO:0009408; P:response to heat; IDA:FlyBase.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR002068; A-crystallin/Hsp20_dom.
DR InterPro; IPR001436; Alpha-crystallin/sHSP_animal.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR PANTHER; PTHR45640; PTHR45640; 1.
DR Pfam; PF00011; HSP20; 1.
DR PRINTS; PR00299; ACRYSTALLIN.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS01031; SHSP; 1.
PE 1: Evidence at protein level;
KW Reference proteome; Stress response.
FT CHAIN 1..199
FT /note="Heat shock protein 67B3"
FT /id="PRO_0000125968"
FT DOMAIN 63..170
FT /note="sHSP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00285"
FT REGION 173..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 127
FT /note="R -> P (in Ref. 1; CAA29788)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 22180 MW; E0A5622177D69C22 CRC64;
MPDIPFVLNL DSPDSMYYGH DMFPNRMYRR LHSRQHHDLD LHTLGLIARM GAHAHHLVAN
KRNGELAALS RGGASNKQGN FEVHLDVGLF QPGELTVKLV NECIVVEGKH EEREDDHGHV
SRHFVRRYPL PKEFDSDAIV STLSEDGVLN ITVPPLVSKE ELKERIIPIK HVGPSDLFQN
GNGHKEAGPA ASASEPEAK
