ID   HSP70_AJECA             Reviewed;         705 AA.
AC   Q00043;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Heat shock 70 kDa protein;
GN   Name=HSP70;
OS   Ajellomyces capsulatus (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=5037;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 26034 / G222B;
RX   PubMed=8926078; DOI=10.1128/iai.64.10.4123-4128.1996;
RA   Allendoerfer R., Maresca B., Deepe G.S. Jr.;
RT   "Cellular immune responses to recombinant heat shock protein 70 from
RT   Histoplasma capsulatum.";
RL   Infect. Immun. 64:4123-4128(1996).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; U46464; AAC05418.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q00043; -.
DR   SMR; Q00043; -.
DR   PRIDE; Q00043; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:CAFA.
DR   GO; GO:0009277; C:fungal-type cell wall; IDA:CAFA.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Stress response.
FT   CHAIN           1..705
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078359"
FT   REGION          624..645
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   705 AA;  77558 MW;  DE944897DF80EA13 CRC64;
     MAPAVGIDLG TTYSCVGIFR DDRIEIIAND QGNRTTPSFV AFTDTERLIG DAAKNQVAMN
     PANTVFDAKR LIGRKFADPE VQADMKHFPF KITDKGGKPV IQVEFKGETK EFTPEEISSM
     VLTKMRETAE AYLGGTVNNA VVTVPAYFND SQRQATKDAG LIAGLNVLRI INEPTAAAIA
     YGLDKKADGE RNVLIFDLGG GTFDVSLLTI EEGIFEVKST AGDTHLGGED FDNRLVNHFV
     SEFKRKFKKI SPAERARALR RSPTACERAK RTLSSAAQTS IEIDSLYEGI DFYTSITRAR
     FEELCQDLFR STMEPVERVL RDAKIDKSSV HEIVLVGGST RIPRIQKLVS DFFNGKEPNK
     SINPDEAVAY GAAVQAAILS GDTSSKSTNE ILLLDVAPLS LGIETAGGVM TPLIKRNTTI
     PTKKSETFST FSDNQPGVLI QVFEGERART KDNNLLGKFE LTGIPRARGV PQIEVTFDVD
     ANGIMNVSAL EKGTRKTNKI VITNDKGRLS KEEIERMLAE AEKYKAEDEA EASRIRPKNG
     LESYAYSLRN SLRHSKVDEK LEAGDKEKLK SEIDKTVQWL DENQTATKEE YESQQKELEA
     VANPIMMKFY AGGEGAPGGF PGAGGPGGFP GGPGAGHASG GGDDGPTVEE VDLKFPMLPL
     PWQLSVRKMH RPFFLFLLFL IFLIFLILFL FYFFLPVRFN ESCFS