ID   HSP70_BRUMA             Reviewed;         644 AA.
AC   P27541;
DT   01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Heat shock 70 kDa protein;
GN   Name=HSP70;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1775166; DOI=10.1016/0166-6851(91)90066-f;
RA   Rothstein N., Rajan T.V.;
RT   "Characterization of an hsp70 gene from the human filarial parasite, Brugia
RT   malayi (Nematoda).";
RL   Mol. Biochem. Parasitol. 49:229-238(1991).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; M68933; AAC17926.1; -; Genomic_DNA.
DR   PIR; A45635; A45635.
DR   AlphaFoldDB; P27541; -.
DR   SMR; P27541; -.
DR   STRING; 6279.P27541; -.
DR   PRIDE; P27541; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0009408; P:response to heat; IEP:WormBase.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Stress response.
FT   CHAIN           1..644
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078297"
FT   REGION          613..644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   644 AA;  70220 MW;  DE07774C8CAB2925 CRC64;
     MSKNAIGIDL GTTYSCVGVF MHGKVEIIAN DQGNRTTPSY VAFTDTERLI GDAAKNQVAM
     NPHNTVFDAN RLIGRKFDDG SVQSDMKHWP FKVVNAGGGK PKVQVEYKGE TKTFTPEEIS
     SMVLVKMKET AEAFLGHAVK DAVITVPAYF NDSQRQATKD SGAIAGLNVL RIINEPTAAA
     IAYGLDKKGH GERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGE DFDNRMVNHF
     VAEFKRNDKK DLASNPRALR RLRTACERAK RTLSSSSQAS IEIDSLFEGI DFYTNITRAR
     FEELCADLFR STMDPVEKAL RDAKMDKAQV HDIVLVGGST RIPKVQKLLS DFFSGKELNK
     SINPDEAVAY GAAVQAAILS GDKSEAVQDL LLLDVAPLSL GIETAGGVMT ALIKRNTTIP
     TKTSETFTTY SDNQPGVLIQ VYEGERALTK DNNLLGKFEL SGIPPAPRGV PQIEVTFDID
     ANGILNVSAQ DKSTGKQNKI TITNDKGRLS KDEIERMVQE AEKYKADDEA QKDRIAAKNA
     LESYAFNMKQ TIEDEKLKDK ISEEDKKKIQ EKCDETVRWL DGNQTAEKDE FEHRQKELES
     VCNPIITKLY QSAGGMPGGM PGGMPGGAPG AGSTGGGPTI EEVD