ID   HSP70_ENCHE             Reviewed;         593 AA.
AC   Q95YL7;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Mitochondrial-type heat shock protein 70;
DE            Short=mit-hsp70;
GN   Name=HSP70;
OS   Encephalitozoon hellem (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=27973;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11880223; DOI=10.1016/s1383-5769(01)00093-9;
RA   Arisue N., Sanchez L.B., Weiss L.M., Muller M., Hashimoto T.;
RT   "Mitochondrial-type hsp70 genes of the amitochondriate protists, Giardia
RT   intestinalis, Entamoeba histolytica, and two microsporidians.";
RL   Parasitol. Int. 51:9-16(2002).
CC   -!- FUNCTION: May act as a chaperone.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; AB056660; BAB69033.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q95YL7; -.
DR   SMR; Q95YL7; -.
DR   VEuPathDB; MicrosporidiaDB:EHEL_110410; -.
DR   VEuPathDB; MicrosporidiaDB:KMI_12g18370; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Chaperone; Nucleotide-binding; Nucleus.
FT   CHAIN           1..593
FT                   /note="Mitochondrial-type heat shock protein 70"
FT                   /id="PRO_0000078402"
SQ   SEQUENCE   593 AA;  64895 MW;  131DC4BC04B78CC8 CRC64;
     MPNANALSKK PSSNIIGIDL GTTNSCVSVV KNGEPVIIEN QEGERTTPSV VSILKDEVLV
     GSQSKSKILT HPKNTVFASK RLIGRKLEDP EVKKYVKGLP FDTTSHCNGD VWIKVDGKKY
     SPAQIGAFIL SKLKRSAESF LNHSVVKSVI TVPAYFNDSQ RQATKDAGRI AGLDVVRVIN
     EPTAAALAYG LDKSARGNIA VYDLGGGTFD ISILELSDGV FHVKATNGDT FLGGEDLDNE
     VVSFIVKDFM EKEGIDLGRD VNALARIKEC AEKVKKDLSS SVVSRIDIPY ICNVGGEAKH
     LSREITRSEF EKIVEKIVNR TIEPCKKALA DAGLDSADIK HVILVGGMTR MPYVRKVVKE
     IFGIEPSTEI NPDEAVAKGA ALQGGVLAGE VDNVLLLDVA PLSLGIELLG GVFSKIMRRN
     TTIPFKETQI FSTSEDNQTD VDIKVYQGER AMAADNKYLG QIKLKNIPPL PRGVPKIEVT
     FESDANGMYR VTAQDSVTRT PQSLEIIPSS GLTEKEIDRM VREGEELKNL DEMKRRKAEV
     TISVGELLRR GYNELRKAPE DSLSKLRKVA RGEDFDLEET EQILLDVKKA ISK