ID   HSP70_LEIAM             Reviewed;         652 AA.
AC   Q07437;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Heat shock 70 kDa protein;
GN   Name=HSP70;
OS   Leishmania amazonensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5659;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC   STRAIN=MHOM/BR/77/LTB0016/C1S1;
RX   PubMed=8139614; DOI=10.1016/0166-6851(93)90108-a;
RA   Bock J.H., Langer P.J.;
RT   "Sequence and genomic organization of the hsp70 genes of Leishmania
RT   amazonensis.";
RL   Mol. Biochem. Parasitol. 62:187-198(1993).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; L14604; AAA53690.1; -; mRNA.
DR   EMBL; L14605; AAD15233.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q07437; -.
DR   SMR; Q07437; -.
DR   PRIDE; Q07437; -.
DR   VEuPathDB; TriTrypDB:LAMA_000514000; -.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..652
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078302"
FT   REGION          619..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         81
FT                   /note="L -> S"
FT   VARIANT         632
FT                   /note="S -> G"
SQ   SEQUENCE   652 AA;  71197 MW;  0B21375DC05EF633 CRC64;
     MTFDGAIGID LGTTYSCVGV WQNDRVEIIA NDQGNRTTPS YVAFTDSERL IGDAAKNQVA
     MNPHNTVFDA KRLIGRKFND LVVQSDMKHW PFKVTTKGDD KPVISVQYRG EEKTFTPEKI
     SSMVLLKMKE TAEAYLGKQV KKAVVTVPAY FNDSQRQATK DAGTISGLEV LRIINEPTAA
     AIAYGLDKGD DGKERNVLIF DLGGGTFDVT LLTIDGGIFE VKATNGDTHL GGEDFDNRLV
     TFFTEEFKRK NKGKNLASSH RSLRRLRTAC ERAKRTLSSA TQATIEIDAL FDNVDFQATI
     NRARFEELCG DLFRSTIQPV ERVLQDAKMD KRSVHDVVLV GGSTRIPKVQ SLVSDFFGGK
     ELNKSINPDE AVAYGAAVQA FILTGGKSKQ TEGLLLLDVT PLTLGIETAG GVMTALIKRN
     TTIPTKKSQI FSTYADNQPG VHIQVFEGER AMTKDCHLLG TFDLSGIPPA PRGVPQIEVT
     FDLDANGILN VSAEEKGTGK RNQITITNDK GRLSKDEIER MVNDAMKYEA DDKAQADRVE
     AKNGLENYAY SMKNTLGDSN VSGKLDDTDK STLNKEIEAA LEWLSSNQEA TKEEYEHKQK
     ELENVCNPIM TKMYQSMGGG AGGMAGMPDM SSMSGARPAG GASSGPKVEE VD