ID   HSP70_LEIDO             Reviewed;         653 AA.
AC   P17804;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Heat shock 70 kDa protein;
GN   Name=HSP70;
OS   Leishmania donovani.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5661;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=MHOM/ET/67/HU3 / LV9;
RX   PubMed=2163842; DOI=10.1111/j.1432-1033.1990.tb15586.x;
RA   Macfarlane J., Blaxter M.L., Bishop R.P., Miles M.A., Kelly J.M.;
RT   "Identification and characterisation of a Leishmania donovani antigen
RT   belonging to the 70-kDa heat-shock protein family.";
RL   Eur. J. Biochem. 190:377-384(1990).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; X52314; CAA36551.1; -; Genomic_DNA.
DR   PIR; S11448; S11448.
DR   AlphaFoldDB; P17804; -.
DR   SMR; P17804; -.
DR   PRIDE; P17804; -.
DR   VEuPathDB; TriTrypDB:LdBPK_283000.1; -.
DR   VEuPathDB; TriTrypDB:LdCL_280034900; -.
DR   VEuPathDB; TriTrypDB:LDHU3_28.3970; -.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..653
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078304"
FT   REGION          616..653
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   653 AA;  71169 MW;  716D85A2C61FE43B CRC64;
     MTFDGAIGID LGTTYSCVGV WQNERVDIIA NDQGNRTTPS YVAFTDSERL IGDAAKNQVA
     MNPHNTVFDA KRLIGRKFND SVVQSDMKHW PFKVTTKGDD KPMIAVQYRG EEKTFTPEEI
     SSMVLLKMKE TAEAYLGKQV KKAVVTVPAY FNDSQRQATK DAGTIAGLEV LRIINEPTRA
     IAYGLDKGDD GKERNVLIFD LGGGTFDVSL LTIDGGIFEV KATNGDTHLG GEDFDNRLVT
     FFTEEFKRKN KGKNLASSHR ALRGLRTACE RAKRTLSSAT QATIEIDALF ENVDFQATIT
     RARFEELCGD LFRSTIQPVE RVLQDAKMDK RSVHDVVLVG GSTRIPKVQS LVSDFFGGKE
     LNKSINPDEA VAYGAAVQAF ILTGGKSKQT EGLLLLDVTP LTLGIETAGG VMTALIKRNT
     TIPTKKSQIF STYADNQPGV HIQVFEGERA MTKDCHLLGT FDLSGIPPAP RGVPQIEVTF
     DLDANGILNV SAEEKGTGKR NQITITNDKG RLSKDEIERM VNDAMKYEAD DRAQRDRVEA
     KNGLENYAYS MKNTLGDSNV SGKLDDSDKA TLNKEIDVTL EWLSSNQEAT KEEYEHKQKE
     LESVCNPIMT KMYQSMGGAG GGMPGGMPDM SGMSGGAGPA GGASSGPKVE EVD