ID   HSP70_LEIMA             Reviewed;         516 AA.
AC   P14834;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Heat shock 70 kDa protein;
DE   Flags: Fragment;
GN   Name=HSP70;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=WR300;
RX   PubMed=3186441; DOI=10.1093/nar/16.20.9567;
RA   Lee M.G., Atkinson B.L., Giannini S.H., van der Ploeg L.H.T.;
RT   "Structure and expression of the hsp 70 gene family of Leishmania major.";
RL   Nucleic Acids Res. 16:9567-9585(1988).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; M36675; AAA29251.1; -; Genomic_DNA.
DR   PIR; S06443; S06443.
DR   AlphaFoldDB; P14834; -.
DR   SMR; P14834; -.
DR   STRING; 5664.LmjF.28.2770; -.
DR   PRIDE; P14834; -.
DR   VEuPathDB; TriTrypDB:LmjF.28.2780; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_280036200; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_280035800; -.
DR   eggNOG; KOG0101; Eukaryota.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..>516
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078305"
FT   NON_TER         516
SQ   SEQUENCE   516 AA;  56535 MW;  36F83ACFCE952452 CRC64;
     MTFDGAIGID LGTTYSCVGV WQNERLDIIA NDQGNRTTPS YVAFTDSERL IGDAAKNQVA
     MNPHNTVFDA KRLIGRKFND SVVQSDMKHW PFKVTTKGDD KPVISVQYRG EEKTFTPEEI
     SSMVLLKMKE TAEAYLGKQV KKAVVTVPAY FNDSQRQATK DAGTIAGLEV VRIINEPTAA
     AIAYGLDKGD DGKERNVLIF DLGGGTFDVT LLTIDRGIFE VKATNGDTHL GGEDFDNRLV
     TFFTEEFKRK NKGKNLASSH RALRRLRTAC ERAKRTLSSA TQATIEIDAL FENIDFQATI
     TRARFEELCG DLFRSTIQPV ERVLQDAKMD KRSVHDVVLV GGSTRIPKVQ SLVSDFFGGK
     ELNKSINPDE AVAYGAAVQA FILTGGKSKQ TEGLLLLDVT PLTLGIETAG GVMTALIKRN
     TTIPTKKSQI FSTYADNQPG VHIQVFEGER AMTKDCHLLG TFDLSGIPPA PRGVPQIEVT
     FDLDANGILN VSAEEKGTGK RNQITITNDK GRLSKD