ID   HSP70_NEUCR             Reviewed;         646 AA.
AC   Q01233; Q7RVI8;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   09-MAY-2003, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=HSP70;
GN   Name=hsps-1; ORFNames=B18E6.040, NCU09602;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7798134; DOI=10.1128/jb.177.1.212-221.1995;
RA   Kapoor M., Curle C.A., Runham C.;
RT   "The hsp70 gene family of Neurospora crassa: cloning, sequence analysis,
RT   expression, and genetic mapping of the major stress-inducible member.";
RL   J. Bacteriol. 177:212-221(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12655011; DOI=10.1093/nar/gkg293;
RA   Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA   Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT   "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT   genome sequence.";
RL   Nucleic Acids Res. 31:1944-1954(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- INDUCTION: By heat shock.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; U10443; AAA82183.1; -; Genomic_DNA.
DR   EMBL; BX284745; CAD70284.1; -; Genomic_DNA.
DR   EMBL; CM002237; EAA34130.1; -; Genomic_DNA.
DR   PIR; T46650; T46650.
DR   RefSeq; XP_963366.1; XM_958273.3.
DR   AlphaFoldDB; Q01233; -.
DR   SMR; Q01233; -.
DR   IntAct; Q01233; 1.
DR   MINT; Q01233; -.
DR   STRING; 5141.EFNCRP00000009412; -.
DR   PRIDE; Q01233; -.
DR   EnsemblFungi; EAA34130; EAA34130; NCU09602.
DR   GeneID; 3879515; -.
DR   KEGG; ncr:NCU09602; -.
DR   VEuPathDB; FungiDB:NCU09602; -.
DR   HOGENOM; CLU_005965_3_0_1; -.
DR   InParanoid; Q01233; -.
DR   OMA; KANPIMM; -.
DR   Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0031072; F:heat shock protein binding; IBA:GO_Central.
DR   GO; GO:0051787; F:misfolded protein binding; IBA:GO_Central.
DR   GO; GO:0044183; F:protein folding chaperone; IBA:GO_Central.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0034620; P:cellular response to unfolded protein; IBA:GO_Central.
DR   GO; GO:0051085; P:chaperone cofactor-dependent protein refolding; IBA:GO_Central.
DR   GO; GO:0042026; P:protein refolding; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Chaperone; Nucleotide-binding; Reference proteome;
KW   Stress response.
FT   CHAIN           1..646
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078372"
FT   REGION          613..646
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        247
FT                   /note="H -> D (in Ref. 1; AAA82183)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        353
FT                   /note="N -> D (in Ref. 1; AAA82183)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        360
FT                   /note="S -> R (in Ref. 1; AAA82183)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   646 AA;  70554 MW;  AB0C8DC5DBE4714A CRC64;
     MAPAVGIDLG TTYSCVGVFR EDRCEIIAND QGNRTTPSFV AFTDTERLVG DAAKNQVAMN
     PANTVFDAKR LIGRKFSDPE VQADMKHFPF KVIDRGGKPV IQVEFKGETK VFTPEEISAM
     ILQKMKETAE AYLGGTVNNA VVTVPAYFND SQRQATKDAG LIAGLNVLRI INEPTAAAIA
     YGLDKKVEGE RNVLIFDLGG GTFDVSLLTI EEGIFEVKST AGDTHLGGED FDNRLVNHFV
     QEFKRKHKKD LSTNARALRR LRTACERAKR TLSSSAQTSI EIDSLFEGID FYTSITRARF
     EELCQDLFRS TLQPVDRVLT DAKIDKSQVH EIVLVGGSTR IPRIQKLISD YFNGKEPNKS
     INPDEAVAYG AAVQAAILSG DTSSKSTSEI LLLDVAPLSL GIETAGGMMT KLIPRNTTIP
     TKKSEVFSTF SDNQPGVLIQ VYEGERQRTK DNNLLGKFEL TGIPPAPRGV PQIEVTFDVD
     ANGIMNVSAL EKGTGKTNQI TITNDKGRLS KEEIERMLAE AEKFKEEDEA EAKRVAAKNG
     LESYAYSLRN TLSDSKVDEK LDAADKEKLK SEIDKIVAWL DENQQATREE YEERQKELEA
     IANPIMMKFY GAGGAPGGMP GAAPGGFPGG APGSNDNEGP TVEEVD