ID   HSP70_ONCMY             Reviewed;         651 AA.
AC   P08108;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1988, sequence version 2.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Heat shock cognate 70 kDa protein;
DE            Short=HSP70;
GN   Name=hsc71;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1371753; DOI=10.1111/j.1432-1033.1992.tb16709.x;
RA   Zafarullah M., Wisniewski J., Shworak N.W., Schieman S., Misra S.,
RA   Gedamu L.;
RT   "Molecular cloning and characterization of a constitutively expressed heat-
RT   shock-cognate hsc71 gene from rainbow trout.";
RL   Eur. J. Biochem. 204:893-900(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-213.
RX   PubMed=6092938; DOI=10.1128/mcb.4.9.1785-1791.1984;
RA   Kothary R.K., Jones D., Candido E.P.M.;
RT   "70-Kilodalton heat shock polypeptides from rainbow trout: characterization
RT   of cDNA sequences.";
RL   Mol. Cell. Biol. 4:1785-1791(1984).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; S85730; AAB21658.1; -; Genomic_DNA.
DR   EMBL; K02550; AAA49563.1; -; mRNA.
DR   PIR; S21175; S21175.
DR   RefSeq; NP_001117704.1; NM_001124232.1.
DR   AlphaFoldDB; P08108; -.
DR   SMR; P08108; -.
DR   PRIDE; P08108; -.
DR   Ensembl; ENSOMYT00000099498; ENSOMYP00000091433; ENSOMYG00000041769.
DR   GeneID; 100135841; -.
DR   KEGG; omy:100135841; -.
DR   CTD; 3312; -.
DR   GeneTree; ENSGT00950000183206; -.
DR   OrthoDB; 288077at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:AgBase.
DR   GO; GO:0016020; C:membrane; IDA:AgBase.
DR   GO; GO:0005634; C:nucleus; IDA:AgBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:1903842; P:response to arsenite ion; IDA:AgBase.
DR   GO; GO:0046686; P:response to cadmium ion; IDA:AgBase.
DR   GO; GO:0046688; P:response to copper ion; IDA:AgBase.
DR   GO; GO:0009408; P:response to heat; IDA:AgBase.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..651
FT                   /note="Heat shock cognate 70 kDa protein"
FT                   /id="PRO_0000078314"
FT   REGION          623..651
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        182..183
FT                   /note="AY -> RT (in Ref. 2; AAA49563)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   651 AA;  71283 MW;  8701630A0CBC4BE0 CRC64;
     MSKGPAVGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDSERL IGDAAKNQVA
     MNPCNTVFDA KRLIGRRFDD GVVQSDMKHW PFEVINDSTR PKLQVEYKGE TKSFYPEEIS
     SMVLVKMKEI AEAYLGKTVN NAVVTVPAYF NDSQRQATKD AGTISGLNVL RIINEPTAAA
     IAYGLDKKVG AERNVLIFDL GGGTFDVSIL TIEDGIFEVK STAGDTHLGG EDFDNRMVNH
     FIAEFKRKYK KDISDNKRAV RRLRTACERA KRTLSSSTQA SIEIDSLYEG IDFYTSITRA
     RFEELNADLF RGTLDPVEKS LRDAKMDKAQ VHDIVLVGGS TRIPKIQKLL QDFFNGKELN
     KSINPDEAVA YGAAVQAAIL SGDKSENVQD LLLLDVTPLS LGIETAGGVM TVLIKRNTTI
     PTKQTQTFTT YSDNQPGVLI QVYEGERAMT KDNNLLGKFE LTGIPPAPRG VPQIEVTFDI
     DANGIMNVSA ADKSTGKENK ITITNDKGRL SKEDIERMVQ EAEKYKCEDD VQRDKVSSKN
     SLESYAFNMK STVEDEKLQG KISDEDKTKI LEKCNEVIGW LDKNQTAEKE EYEHHQKELE
     KVCNPIITKL YQGAGGMPGG MPEGMAGGFP GAGGAAPGGG GSSGPTIEEV D