ID   HSP70_ONCVO             Reviewed;         322 AA.
AC   P11503;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Heat shock 70 kDa protein;
DE            Short=HSP70;
DE   Flags: Fragment;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2704388; DOI=10.1016/0166-6851(89)90084-4;
RA   Rothstein N.M., Higashi G., Yates J., Rajan T.V.;
RT   "Onchocerca volvulus heat shock protein 70 is a major immunogen in
RT   amicrofilaremic individuals from a filariasis-endemic area.";
RL   Mol. Biochem. Parasitol. 33:229-236(1989).
CC   -!- MISCELLANEOUS: Heat shock protein 70 is a major immunogen in a
CC       microfilaremic individuals from a filariasis-endemic area.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; J04006; AAA29417.1; -; mRNA.
DR   AlphaFoldDB; P11503; -.
DR   SMR; P11503; -.
DR   STRING; 6282.P11503; -.
DR   HOGENOM; CLU_005965_1_0_1; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   GO; GO:0006950; P:response to stress; IEA:UniProt.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Stress response.
FT   CHAIN           <1..>322
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078309"
FT   NON_TER         1
FT   NON_TER         322
SQ   SEQUENCE   322 AA;  35614 MW;  2BA3A2E8155A7180 CRC64;
     EFKRNDKKDL ASNPRALRRL RTACERAKRT LSSSSQASIE IDSLFEGIDF YTNITRARFE
     ELCADLFRST MDPVEKALRV AKMDKAQVHD IVLVGGSTRI PKVQKLLSDF FSGKELNKSI
     NPDEAVAYGA AVQAAILSGD KSEAVQDLLL LDVAPLSLGI ETAGGVMTAL IKRNTTIPTK
     TSQTFTTYSD NQPGVLIQVY EGERAMTKDN NLLGKFELSG IPPAPRGVPQ IEVTFDIDAN
     GILNVSAQDK STGKQNKITI TNDKGRLSKD EIERMVQEAE KYKADDEAQK DRIAAKNALE
     SYAFNMKQTI EDEKLKDKIS EF