ID   HSP70_PLAFA             Reviewed;         681 AA.
AC   P11144;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Heat shock 70 kDa protein;
DE            Short=HSP70;
DE   AltName: Full=74.3 kDa protein;
DE   AltName: Full=Cytoplasmic antigen;
OS   Plasmodium falciparum.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=5833;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2448622; DOI=10.1016/0166-6851(87)90130-7;
RA   Yang Y.-F., Tan-Ariya P., Sharma Y.D., Kilejian A.;
RT   "The primary structure of a Plasmodium falciparum polypeptide related to
RT   heat shock proteins.";
RL   Mol. Biochem. Parasitol. 26:61-68(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 367-681.
RX   PubMed=3095842; DOI=10.1073/pnas.83.22.8713;
RA   Bianco A.E., Favaloro J.M., Burkot T.R., Culvenor J.G., Crewther P.E.,
RA   Brown G.V., Anders R.F., Coppel R.L., Kemp D.J.;
RT   "A repetitive antigen of Plasmodium falciparum that is homologous to heat
RT   shock protein 70 of Drosophila melanogaster.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:8713-8717(1986).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; M19753; AAA29626.1; -; mRNA.
DR   PIR; B31238; B31238.
DR   PIR; JU0164; JU0164.
DR   AlphaFoldDB; P11144; -.
DR   SMR; P11144; -.
DR   ChEMBL; CHEMBL5193; -.
DR   PRIDE; P11144; -.
DR   EnsemblProtists; CAD51185; CAD51185; PF3D7_0818900.
DR   VEuPathDB; PlasmoDB:PF3D7_0818900; -.
DR   VEuPathDB; PlasmoDB:Pf7G8-2_000234200; -.
DR   VEuPathDB; PlasmoDB:Pf7G8_080024000; -.
DR   VEuPathDB; PlasmoDB:PfCD01_080024500; -.
DR   VEuPathDB; PlasmoDB:PfDd2_080024100; -.
DR   VEuPathDB; PlasmoDB:PfGA01_080022600; -.
DR   VEuPathDB; PlasmoDB:PfGB4_080023700; -.
DR   VEuPathDB; PlasmoDB:PfGN01_080024600; -.
DR   VEuPathDB; PlasmoDB:PfHB3_080024400; -.
DR   VEuPathDB; PlasmoDB:PfIT_080023900; -.
DR   VEuPathDB; PlasmoDB:PfKE01_080024500; -.
DR   VEuPathDB; PlasmoDB:PfKH01_080024000; -.
DR   VEuPathDB; PlasmoDB:PfKH02_080024500; -.
DR   VEuPathDB; PlasmoDB:PfML01_080024500; -.
DR   VEuPathDB; PlasmoDB:PfNF135_000025500; -.
DR   VEuPathDB; PlasmoDB:PfNF166_080022700; -.
DR   VEuPathDB; PlasmoDB:PfNF54_080022700; -.
DR   VEuPathDB; PlasmoDB:PfSD01_080024300; -.
DR   VEuPathDB; PlasmoDB:PfSN01_080023500; -.
DR   VEuPathDB; PlasmoDB:PfTG01_080024800; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..681
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078311"
FT   REGION          655..681
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        648..651
FT                   /note="Missing (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        681
FT                   /note="D -> AEF (in Ref. 2)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   681 AA;  74287 MW;  5873A01394C2189A CRC64;
     MASAKGSKPN LPESNIAIGI DLGTTYSCVG VWRNENVDII ANDQGNRTTP SYVAFTDTER
     LIGDAAKNQV ARNPENTVFD AKRLIGRKFT ESSVQSDMKH WPFTVKSGVD EKPMIEVTYQ
     GEKKLFHPEE ISSMVLQKMK ENAEAFLGKS IKNAVITVPA YFNDSQRQAT KDAGTIAGLN
     VMRIINEPTA AAIAYGLHKK GKGEKNILIF DLGGGTFDVS LLTIEDGIFE VKATAGDTHL
     GGEDFDNRLV NFCVEDFKRK NRGKDLSKNS RALRRLRTQC ERAKRTLSSS TQATIEIDSL
     FEGIDYSVTV SRARFEELCI DYFRDTLIPV EKVLKDAMMD KKSVHEVVLV GGSTRIPKIQ
     TLIKEFFNGK EACRSINPDE AVAYGAAVQA AILSGDQSNA VQDLLLLDVC SLSLGLETAG
     GVMTKLIERN TTIPAKKSQI FTTYADNQPG VLIQVYEGER ALTKDNNLLG KFHLDGIPPA
     PRKVPQIEVT FDIDANGILN VTAVEKSTGK QNHITITNDK GRLSQDEIDR MVNDAEKYKA
     EDEENRKRIE ARNSLENYCY GVKSSLEDQK IKEKLQPAEI ETCMKTITTI LEWLEKNQLA
     GKDEYEAKQK EAESVCAPIM SKIYQDAAGA AGGMPGGMPG GMPGGMPSGM PGGMNFPGGM
     PGAGMPGNAP AGSGPTVEEV D