ID   HSP70_SCHMA             Reviewed;         637 AA.
AC   P08418;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 2.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Heat shock 70 kDa protein homolog;
DE            Short=HSP70;
DE   AltName: Full=Major surface antigen;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1484560; DOI=10.1016/0166-6851(92)90188-p;
RA   Neumann S., Ziv E., Lanter F., Schechter I.;
RT   "Cloning and sequencing of an hsp70 gene of Schistosoma mansoni.";
RL   Mol. Biochem. Parasitol. 56:357-360(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 19-637.
RX   PubMed=3106556; DOI=10.1084/jem.165.5.1430;
RA   Hedstrom R., Culpepper J., Harrison R.A., Agabian N., Newport G.;
RT   "A major immunogen in Schistosoma mansoni infections is homologous to the
RT   heat-shock protein Hsp70.";
RL   J. Exp. Med. 165:1430-1435(1987).
CC   -!- FUNCTION: Major immunogen in Schistosoma mansoni infections. Possibly
CC       plays an important role in parasite development and pathogenesis.
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; L02415; AAA29898.1; -; Genomic_DNA.
DR   EMBL; X05384; CAA28976.1; -; mRNA.
DR   PIR; A48469; A48469.
DR   AlphaFoldDB; P08418; -.
DR   SMR; P08418; -.
DR   STRING; 6183.Smp_106930.1; -.
DR   PRIDE; P08418; -.
DR   eggNOG; KOG0101; Eukaryota.
DR   HOGENOM; CLU_005965_3_0_1; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Stress response.
FT   CHAIN           1..637
FT                   /note="Heat shock 70 kDa protein homolog"
FT                   /id="PRO_0000078319"
FT   REGION          615..637
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        69
FT                   /note="K -> T (in Ref. 2; CAA28976)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        114
FT                   /note="A -> P (in Ref. 2; CAA28976)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        251..253
FT                   /note="IRS -> NRG (in Ref. 2; CAA28976)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        289
FT                   /note="T -> I (in Ref. 2; CAA28976)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        381
FT                   /note="E -> D (in Ref. 2; CAA28976)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        564
FT                   /note="R -> H (in Ref. 2; CAA28976)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   637 AA;  69875 MW;  A7786D2EB0A11E19 CRC64;
     MPNAIGIDLG TTYSCVGVFQ HGKVEIIAND QGNRTTPSYV AFTDSERLIG DGAKNQVAMN
     PTNTVFDAKR LIGRRFDDPS VQSDMKHWPF EVTQVGGKLK ICVEYKGEKK MFSAEEISSM
     VLTKMKEVAE SYLGRTVSDA VITVPAYFND SQRQATKDAG AIAGLNVLRI INEPTAAAIA
     YGLDKKVGGE RNVLIFDLGG GTFDVSILTI EDGIFEVKST AGDTHLGGED FDNRMVDHFV
     KEFQKKYNKD IRSNKRALRR LRTACERAKR TLSSSAQTNL EIDSLCDGTD FYTVITRARF
     EELNADLFRG TLDPVEKALR DAKMDKSQIH DIVLVGGSTR IPKVQKLLQD FFNGKELNKS
     INPDEAVAYG AAVQAAILSG EKCEAVQDLL LLDVAPLSLG LETAGGVMTA LIKRNTTIPT
     KQTQTFTTYS DNQPGVLIQV FEGERALTKD NNLLGKFELS GIPPAPRGTP QIEVTFDIDA
     NGILNVSAVD KGTGKQNKIT ITNDKGRLSK EEIERMVADA DKYKAEDEKQ RDRVSAKNSL
     ESYVYTMKQQ VEGELKEKIP ESDRQVIISK CEDTISWLDV HQSAEKHEYE SKREELEKVC
     APIITKVYQA GGMPGGMHEA SGAGGGSGKG PTIEEVD