ID   HSP70_THEPA             Reviewed;         647 AA.
AC   Q27031; Q4N5Y9;
DT   18-APR-2006, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 2.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Heat shock 70 kDa protein;
DE   AltName: Full=70 kDa heat shock protein;
DE   AltName: Full=HSP 70.1;
GN   OrderedLocusNames=TP02_0148;
OS   Theileria parva (East coast fever infection agent).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Piroplasmida;
OC   Theileriidae; Theileria.
OX   NCBI_TaxID=5875;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Muguga;
RX   PubMed=9106200; DOI=10.1016/s0166-6851(97)02831-4;
RA   Daubenberger C., Heussler V., Gobright E., Wijngaard P., Clevers H.C.,
RA   Wells C., Tsuji N., Musoke A., McKeever D.;
RT   "Molecular characterisation of a cognate 70 kDa heat shock protein of the
RT   protozoan Theileria parva.";
RL   Mol. Biochem. Parasitol. 85:265-269(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Muguga;
RX   PubMed=15994558; DOI=10.1126/science.1110439;
RA   Gardner M.J., Bishop R., Shah T., de Villiers E.P., Carlton J.M., Hall N.,
RA   Ren Q., Paulsen I.T., Pain A., Berriman M., Wilson R.J.M., Sato S.,
RA   Ralph S.A., Mann D.J., Xiong Z., Shallom S.J., Weidman J., Jiang L.,
RA   Lynn J., Weaver B., Shoaibi A., Domingo A.R., Wasawo D., Crabtree J.,
RA   Wortman J.R., Haas B., Angiuoli S.V., Creasy T.H., Lu C., Suh B.,
RA   Silva J.C., Utterback T.R., Feldblyum T.V., Pertea M., Allen J.,
RA   Nierman W.C., Taracha E.L.N., Salzberg S.L., White O.R., Fitzhugh H.A.,
RA   Morzaria S., Venter J.C., Fraser C.M., Nene V.;
RT   "Genome sequence of Theileria parva, a bovine pathogen that transforms
RT   lymphocytes.";
RL   Science 309:134-137(2005).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; U40190; AAB53893.1; -; mRNA.
DR   EMBL; AAGK01000002; EAN32434.1; -; Genomic_DNA.
DR   RefSeq; XP_764717.1; XM_759624.1.
DR   AlphaFoldDB; Q27031; -.
DR   SMR; Q27031; -.
DR   STRING; 5875.XP_764717.1; -.
DR   PRIDE; Q27031; -.
DR   EnsemblProtists; EAN32434; EAN32434; TP02_0148.
DR   GeneID; 3502280; -.
DR   KEGG; tpv:TP02_0148; -.
DR   VEuPathDB; PiroplasmaDB:TpMuguga_02g00148; -.
DR   eggNOG; KOG0101; Eukaryota.
DR   InParanoid; Q27031; -.
DR   OMA; KANPIMM; -.
DR   Proteomes; UP000001949; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Stress response.
FT   CHAIN           1..647
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000232678"
FT   REGION          615..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        445
FT                   /note="E -> K (in Ref. 1; AAB53893)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   647 AA;  71033 MW;  0975E74B487D2B0E CRC64;
     MTGPAIGIDL GTTYSCVAVY KDNNVEIIPN DQGNRTTPSY VAFTDTERLI GDAAKNQEAR
     NPENTIFDAK RLIGRKFDDR TVQEDMKHWP FKVTNGPNGK PNIEVTFQGE KKTFHAEEIS
     SMVLTKMKEI AEAFLGKSVK DVVITVPAYF NDSQRQATKD AGTIAGLNVM RIINEPTAAA
     IAYGLDKKGG GEKNVLIFDL GGGTFDVSIL TIEDGIFEVK ATAGDTHLGG EDFDNLLVEH
     CVRDFMRLNN GKNISSNKRA LRRLRTHCER AKRVLSSSTQ ATIELDSLYE GIDYNTTISR
     ARFEELCNEK FRSTLVPVEK ALESSGLDKR SIHEVVLVGG STRIPKIQTL IKNFFNGKEP
     CRSINPDEAV AYGAAVQAAI LSGNQSEKIQ ELLLLDVAPL SLGLETAGGV MTVLIKRNTT
     IPTKKNQIFT TNEDRQEGVL IQVFEGERAM TKDNNLLGKF HLTGIAPAPR GVPQIEVTFD
     IDANGILNVT AMDKSTGKSE HVTITNDKGR LSQEEIDRMV EEAEKYKEED EKRRKCVESK
     HKLENYCYSM KNTLSEDQVK QKLGADEVDN ALNTITEALK WVETNQLAEH DEFEDKLKHV
     EGVCNPLVTK LYQSGGAPGA GPDMGAGFPG GAPPPSSSSG PTVEEVD