ID   HSP70_TRYCR             Reviewed;         680 AA.
AC   P05456;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Heat shock 70 kDa protein;
GN   Name=HSP70;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2831499; DOI=10.1093/nar/16.4.1393;
RA   Requena J.M., Lopez M.C., Jimenez-Ruyiz A., de la Torre J.C., Alonso C.;
RT   "A head-to-tail tandem organization of hsp70 genes in Trypanosoma cruzi.";
RL   Nucleic Acids Res. 16:1393-1406(1988).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X07083; CAA30115.1; -; Genomic_DNA.
DR   PIR; S06158; S06158.
DR   AlphaFoldDB; P05456; -.
DR   SMR; P05456; -.
DR   PRIDE; P05456; -.
DR   VEuPathDB; TriTrypDB:BCY84_19548; -.
DR   VEuPathDB; TriTrypDB:C3747_108g107; -.
DR   VEuPathDB; TriTrypDB:C4B63_6g315; -.
DR   VEuPathDB; TriTrypDB:Tc_MARK_1461; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0077200; -.
DR   VEuPathDB; TriTrypDB:TcCL_ESM03828; -.
DR   VEuPathDB; TriTrypDB:TcCLB.510439.61; -.
DR   VEuPathDB; TriTrypDB:TcCLB.511211.170; -.
DR   VEuPathDB; TriTrypDB:TcCLB.511257.10; -.
DR   VEuPathDB; TriTrypDB:TCDM_07868; -.
DR   VEuPathDB; TriTrypDB:TcG_05979; -.
DR   VEuPathDB; TriTrypDB:TCSYLVIO_008232; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0011560; -.
DR   GO; GO:0043226; C:organelle; IEA:UniProt.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Nucleotide-binding; Stress response.
FT   CHAIN           1..680
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078323"
FT   REGION          643..680
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  73809 MW;  D102000F5B7A8D82 CRC64;
     MTYEGAIGID LGTTYSCVGV WQNERVEIIA NDQGNRTTPS YVAFTDSERL IGDAAKNQVA
     MNPRNTVFDA KRLIGRKFSD PVVQSDMKHW PFKVITKGDD KPVIQVQFRG ETKTFNPEEV
     SSMVLSKMKE IAESYLGKQV KKAVVTVPAY FNDSQRQATK DAGTIAGLEV LRIINEPTAA
     AIAYGLDKVE DGKERNVLIF DLGGGTFDVT LLTIDGGIFE VKATNGDTHL GGEDFDNRLV
     AHFTDEFKRK NKGKDLSTNL RALRRLRTAC ERAKRTLSSA AQATIEIDAL FDNVDFQATI
     TRARFEELCG ELFRGTLQPV ERVLQDAKMD KRAVHDVVLV GGSTRIPKVM QLVSDFFRGK
     ELKKSIQPDE AVAYGAAVQA FILTGGKSKQ TEGLLLLDVT PLTLGIETAG GVMTSLIKRN
     TTIPTKKSQI FSTYADNQPG VHIQVFEGER AMTKDCHLLG TFELSGIPPP PRGVPQIEVT
     FDLDANGILN VSAEEKGTGK RNQIVLTNDK GRLSRAEIER MVREAAKYEA EDKDQVRQID
     AKNGLENYAF SMKNAVNDPN VAGKIEEADK KTITSAVEEA LEWLNNNQEA SKEEYEHRQK
     ELENLCTPIM TNMYQGMAGA GMPGGMPGGM PGGMPGGMPG GMPGGMPGGM PGGMPGGMPG
     GMPGGANPSS SSGPEVEEVD