ID   HSP70_XENLA             Reviewed;         647 AA.
AC   P02827;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Heat shock 70 kDa protein;
DE            Short=HSP70;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=6510409; DOI=10.1002/j.1460-2075.1984.tb02159.x;
RA   Bienz M.;
RT   "Xenopus hsp 70 genes are constitutively expressed in injected oocytes.";
RL   EMBO J. 3:2477-2483(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 81-120.
RX   PubMed=6203112; DOI=10.1073/pnas.81.10.3138;
RA   Bienz M.;
RT   "Developmental control of the heat shock response in Xenopus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 81:3138-3142(1984).
CC   -!- SIMILARITY: Belongs to the heat shock protein 70 family. {ECO:0000305}.
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DR   EMBL; X01102; CAA25576.1; -; Genomic_DNA.
DR   EMBL; K02307; AAA49759.1; -; mRNA.
DR   PIR; A03310; HHXL70.
DR   RefSeq; NP_001121147.1; NM_001127675.1.
DR   AlphaFoldDB; P02827; -.
DR   SMR; P02827; -.
DR   BioGRID; 99675; 1.
DR   IntAct; P02827; 1.
DR   PRIDE; P02827; -.
DR   DNASU; 398343; -.
DR   GeneID; 398343; -.
DR   KEGG; xla:398343; -.
DR   CTD; 398343; -.
DR   Xenbase; XB-GENE-485630; hsp70.L.
DR   OrthoDB; 288077at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 398343; Expressed in egg cell and 18 other tissues.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0140662; F:ATP-dependent protein folding chaperone; IEA:InterPro.
DR   Gene3D; 1.20.1270.10; -; 1.
DR   Gene3D; 2.60.34.10; -; 1.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR018181; Heat_shock_70_CS.
DR   InterPro; IPR029048; HSP70_C_sf.
DR   InterPro; IPR029047; HSP70_peptide-bd_sf.
DR   InterPro; IPR013126; Hsp_70_fam.
DR   PANTHER; PTHR19375; PTHR19375; 1.
DR   Pfam; PF00012; HSP70; 1.
DR   SUPFAM; SSF100920; SSF100920; 1.
DR   SUPFAM; SSF100934; SSF100934; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00297; HSP70_1; 1.
DR   PROSITE; PS00329; HSP70_2; 1.
DR   PROSITE; PS01036; HSP70_3; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Nucleotide-binding; Reference proteome; Stress response.
FT   CHAIN           1..647
FT                   /note="Heat shock 70 kDa protein"
FT                   /id="PRO_0000078324"
FT   REGION          622..647
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   647 AA;  70915 MW;  33AFA9EBBFA2FE23 CRC64;
     MATKGVAVGI DLGTTYSCVG VFQHGKVEII ANDQGNRTTP SYVAFTDTER LIGDAAKNQV
     AMNPQNTVFD AKRLIGRKFN DPVVQCDLKH WPFQVVSDEG KPKVKVEYKG EEKSFFPEEI
     SSMVLTKMKE TAEAYLGHPV TNAVITVPAY FNDSQRQATK DAGVLAGLNI LRIINEPTAA
     AIAYGLDKGA RGEQNVLIFD LGGGTFDVSI LTIDDGIFEV KATAGDTHLG GEDFDNRMVN
     HFVEEFKRKH KKDIGQNKRA LRRLRTACDR AKRTLSSSSQ ASIEIDSLFE GIDFYTAITR
     ARFEELCSDL FRGTLEPVEK ALRDAKLDKS QIHEIVLVGG STRIPKVQKL LQDFFNGREL
     NKSINPDEAV AYGAAVQAAI LMGDKSENVQ DLLLLDVAPL SLGLETAGGV MTVLIKRNTT
     IPTKQTQSFT TYSDNQPGVL IQVFEGERAM TKDNNLLGKF ELSGIPPAPR GVPQIEVTFD
     IDANGILNVS AVEKSSGKQN KITITNDKGR LSKEDIEKMV QEAEKYKADD DAQRERVDAK
     NALESYAFNL KSMVEDENVK GKISDEDKRT ISEKCTQVIS WLENNQLAEK EEYAFQQKDL
     EKVCQPIITK LYQGGVPGGV PGGMPGSSCG AQARQGGNSG PTIEEVD